Regular Article
Hereditary intestinal cancer

https://doi.org/10.1006/scbi.2000.0148Get rights and content

Abstract

Mechanisms involved in hereditary intestinal cancer are likely to play a role in sporadic tumorigenesis as well. Studies focusing on the molecular biology underlying these syndromes has contributed considerably to our knowledge on molecular bases of malignant transformation. It can be concluded, that there are two aspects to the importance of studies on intestinal cancer predisposition. First, the families suffering from cancer proneness need help which can, to some extent, be provided through molecular genetic studies. Second, the resources appointed to such research have produced scientific advances with outstanding importance to our understanding of common malignant diseases.

References (131)

  • H Ando et al.

    Detection of 12 germ-line mutations in the adenomatous polyposis coli gene by polymerase chain reaction

    Gastroenterology

    (1993)
  • E Fulcheri et al.

    Significance of the smooth muscle cell component in Peutz–Jeghers and juvenile polyposis

    Hum Pathol

    (1991)
  • KF Heiss et al.

    Malignant risk in juvenile polyposis coli: increasing documentation in the pediatric age group

    J Pediatr Surg

    (1993)
  • OS Salem et al.

    Cowden’s disease (multiple hamartoma and neoplasia syndrome). A case report and review of the English literature

    J. Am Acad Dermatol

    (1983)
  • V Stambolic et al.

    Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

    Cell

    (1998)
  • HF Vasen et al.

    New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC

    Gastroenterology

    (1999)
  • HT Lynch et al.

    Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review

    Gastroenterology

    (1993)
  • J-P Mecklin et al.

    Cancer family syndrome. Genetic analysis of 22 Finnish kindreds

    Gastroenterology

    (1986)
  • R Sankila et al.

    Better survival rates in patients with MLH1-associated hereditary colorectal cancer

    Gastroenterology

    (1996)
  • FS Leach et al.

    Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

    Cell

    (1993)
  • JJ Mulvihill

    The frequency of hereditary large bowel cancer

  • HJ Järvinen et al.

    Screening for gastrointestinal cancer in high-risk groups

    Dig Dis

    (1989)
  • HJ Järvinen

    Epidemiology of familial adenomatous polyposis in Finland: Impact of family screening of the colorectal cancer rate and survival

    Gut

    (1992)
  • LA Aaltonen et al.

    Incidence of hereditary nonpolyposis colorectal cancer, and molecular screening for the disease

    N Engl J Med

    (1998)
  • LA Aaltonen et al.

    A novel approach to estimate the proportion of hereditary non-polyposis colorectal cancer of total colorectal cancer burden

    Cancer Detect Prev

    (1994)
  • RS Houlston et al.

    Dominant genes for colorectal cancer are not rare

    Ann Hum Genet

    (1992)
  • C Dukes

    The hereditary factor in polyposis intestini, or multiple adenomata

    Cancer Rev

    (1930)
  • EJ Gardner et al.

    Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomas

    Am J Hum Genet

    (1953)
  • I Nishisho et al.

    Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

    Science

    (1991)
  • HJ R Bussey

    Familial polyposis coli

    (1975)
  • HF Vasen et al.

    Familial adenomatous polyposis and its clinical surveillance

    Neth J Med

    (1993)
  • J Utsunomiya

    Pathological and genetic aspects of adenomatosis coli in Japan

  • HJ Järvinen et al.

    Biliary involvement in familial adenomatosis coli

    Dis Colon Rectum

    (1983)
  • S Bülow

    Clinical features in familial polyposis coli

    Dis Colon Rectum

    (1986)
  • ML Bisgaard et al.

    Familial adenomatous polyposis (FAP): Frequency, penetrance and mutation rate

    Hum Mut

    (1994)
  • T Jones et al.

    Periampullary malignancy in Gardner’s syndrome

    Ann Surg

    (1977)
  • RO Plail et al.

    Adenomatous polyposis: an association with carcinoma of the thyroid

    Br J Surg

    (1987)
  • JE Kingston et al.

    Association between hepatoblastoma and polyposis coli

    Arch Dis Childhood

    (1983)
  • FP Li et al.

    Hepatoblastoma in families with polyposis coli

    JAMA

    (1987)
  • JE Garber et al.

    Hepatoblastoma and familial adenomatous polyposis

    J. Natl Cancer Inst

    (1988)
  • M Kropilak et al.

    Brain tumors in familial adenomatous polyposis

    Dis Colon Rectum

    (1989)
  • J Utsunomiya et al.

    The occult osteomatous changes in the mandible in patients with familial polyposis coli

    Br J Surg

    (1975)
  • S Bülow et al.

    Mandibular osteomas in familial polyposis coli

    Dis Colon Rectum

    (1984)
  • JO Søndergaard et al.

    Dental anomalies in familial adenomatous polyposis coli

    Acta Odont Scand

    (1987)
  • B Leppard et al.

    Epidermoid cysts, polyposis of coli and Gardner’s syndrome

    Br J Surg

    (1975)
  • EI Traboulsi et al.

    Prevalence and importance of pigmented ocular fundus lesions in Gardner’s syndrome

    N Engl J Med

    (1987)
  • M Leppert et al.

    Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps

    N Engl J Med

    (1990)
  • HT Lynch et al.

    Flat adenomas in a colon cancer- prone kindred

    J Natl Can- cer Institute

    (1988)
  • HT Lynch et al.

    Upper gastrointestinal manifestations in families with hereditary flat adenoma syndrome

    Cancer

    (1993)
  • L Spirio et al.

    Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus

    Am J Hum Genet

    (1992)

    • Cited by (0)

    View full text
    Copyright © 2000 Academic Press. All rights reserved.