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Forkhead Transcription Factors pp 47–59Cite as

The Biology of FoxP3: A Key Player in Immune Suppression during Infections, Autoimmune Diseases and Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

The Transcription factor FoxP3belongs to the forkhead/winged-helix familyoftranscriptional regulators and shares general structural features with other FoxP family members. FoxP3 functions as a master of transcription for the development of regulatory T-cells (Treg cells) both in humans and in mice. Natural genetic mutations of FoxP3 that disrupt its function in humans result in an autoimmune syndrome called Immune Polyendocrinopathy, Enteropathy, X-linked (IPEX) and in mice, its deletion causes the Scurfy phenotype, with similar pathology. The finding that FoxP3 is required for the development and function of Tregs has led to an explosion of research in determining its regulation and function in the immune system. Understanding the biological properties of FoxP3 has a wide range of implications for immune tolerance, autoimmune disorders, inflammation and immune response to infectious diseases and cancer.

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Authors and Affiliations

  1. Department of Microbiology, New York University School of Medicine, Smilow Research Center, 522 FirstAvenue, Smilow Building Rm: 1011, New York, New York, 10016, USA

    Frances Mercer

  2. Department of Microbiology, NYU Cancer Institute, New York, New York, USA

    Derya Unutmaz

  3. New York University School of Medicine, New York, New York, USA

    Derya Unutmaz

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  1. Frances Mercer
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Correspondence to Derya Unutmaz .

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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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Mercer, F., Unutmaz, D. (2009). The Biology of FoxP3: A Key Player in Immune Suppression during Infections, Autoimmune Diseases and Cancer. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_4

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