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Adjuvant Therapy of Primary Breast Cancer VI pp 63–70Cite as

IGF-I Physiology and Breast Cancer

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 152))

Abstract

Knowledge regarding the insulin-like growth factor (IGF) system is increasing rapidly (Jones and Clemmons 1995; Clemmons 1997). Recent research has revealed considerable complexity of the IGF system of mitogens at both the cellular and whole-organism levels. There is evidence to suggest that IGF physiology may be relevant to the pathophysiology of neoplasia in general, and of breast cancer in particular. This review will emphasize recent data of potential interest to clinicians, emphasizing recent results that suggest that IGF-I physiology may be related to risk of breast cancer, and also the rationale for adjuvant breast cancer therapies that target IGF-I.

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Author information

Authors and Affiliations

  1. Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada

    M. Pollak

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  1. M. Pollak
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Editor information

Editors and Affiliations

  1. Zentrum für Tumordiagnostik und Prävention, Rorschacherstrasse 150, CH-9006, St. Gallen, Switzerland

    Hans-Jörg Senn

  2. Dana Farber Cancer Institute Biostatistics, 44 Binney Street, Boston, 02115, USA

    Richard D. Gelber Ph.D

  3. Ospedale Civico, CH-6900, Lugano, Switzerland

    Aron Goldhirsch

  4. Klinik C für Innere Medizin Abteilung für Onkologie und Hämatologie, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland

    Beat Thürlimann

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© 1998 Springer-Verlag Berlin · Heidelberg

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Pollak, M. (1998). IGF-I Physiology and Breast Cancer. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Primary Breast Cancer VI. Recent Results in Cancer Research, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45769-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-45769-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45771-5

  • Online ISBN: 978-3-642-45769-2

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