Skip to main content
Log in

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Almeida JD Oriel JD, Stannard LM (1969) Characterization of the virus found in human genital warts. Microbios 3:225–232

    Google Scholar 

  • Band V, De Caprio JA, Delmolina L, Kulesa V, Sager R (1991) Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J Virol 65:6671–6676

    PubMed  Google Scholar 

  • Barr BB, Benton EC, McLaren K, Bunney MH, Smith IW, Blessing K, Hunter JA (1989) Human papilloma virus infection and skin cancer in renal allograft recipients. Lancet 1, 124–129

    PubMed  Google Scholar 

  • Bartsch D, Boye B, Baust C, zur Hausen H, Schwarz E (1992) Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor β gene in non-tumorigenic and tumorigenic. HeLa hybrid cells. EMBO J 11:2283–2291

    PubMed  Google Scholar 

  • Beijerinck MW (1898) Über ein Contagium vivum fluidum als Ursache der Fleckenkrankheit der Tabakblätter. Verhandl Koninkl Akad Wetenschappen te Amsterdam 6:3–22

    Google Scholar 

  • Berkhout RJM, Tieben LM, Smits HL, Bouwes-Bavinck JN, Vermeer BJ, der Schegget J (1995) Detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients: a nested approach. J Clin Microbiol 33:690–695

    PubMed  Google Scholar 

  • Bernard H-U, Chan S-Y, Delius H (1994) Evolution of papillomaviruses. Curr Top Microbiol Immunol 186:33–54

    PubMed  Google Scholar 

  • Black PH, Hartley JW, Rowe WP, Huebner RJ (1963) Transformation of bovine tissue culture cells by bovine papilloma virus. Nature 199:1016–1018

    PubMed  Google Scholar 

  • Boiron M, Levy J-P, Thomas M, Friedmann JC, Bernard J (1964) Some properties of bovine papilloma virus. Nature 201:423–424

    PubMed  Google Scholar 

  • Bosch FX, Manos MM, Muñoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV (1995) Int. Biol. Study Cervical Cancer (IBSSC) Study Group. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 87:796–802

    PubMed  Google Scholar 

  • Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer and in cell lines derived from gential cancer. EMBO J 3:1151–1157

    PubMed  Google Scholar 

  • Breitburd F, Kirnbauer R, Hubbert NL, Nonnenmacher B, Trin-Dinh-Desmarquet C, Orth G, Schiller JT, Lowy DR (1995) Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J Virol 69:3959–3963

    PubMed  Google Scholar 

  • Chellappan S, Kraus V, Kroger B, Münger K, Howley PM, Phelps W, Nevins JR (1992) Adenovirus E1A, simian virus 40 tumor antigen, human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 89:4549–4553

    PubMed  Google Scholar 

  • Chen EY, Howley PM, Levinson AD, Seeburg PH (1982) The primary structure and genetic organization of the bovine papillomavirus (BPV) type 1 genome. Nature 299:529–534

    PubMed  Google Scholar 

  • Chen T-M, Pecoraro G, Defendi V (1993) Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. Cancer Res 53:1167–1171

    PubMed  Google Scholar 

  • Ciuffo G (1907) Innesto positivo con filtrado di verrucae volgare. G Ital Mal Venereol 48:12–17

    Google Scholar 

  • Coggin JR, zur Hausen H (1979) Workshop on papilloma viruses and cancer. Cancer Res 39:545–546

    Google Scholar 

  • Crawford LV, Crawford EM (1963) A comparative study of polyoma and papilloma viruses. Virology 21:258–263

    PubMed  Google Scholar 

  • DeCaprio JA, Ludlow JW, Figge J, Shew J-Y, Huang C-M, Lee W-H, Marsilio E, Paucha E, Livingston DM (1988) SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283

    PubMed  Google Scholar 

  • Delescluse C, Prunieras M, Regnier M, Moreno G, Aroute J (1972) Epidermodysplasia verruciformis. I. Electron microscope autoradiography and tissue culture studies. Arch Dermatol Forsch 242:202–215

    PubMed  Google Scholar 

  • de Villiers E-M, Gissmann L, zur Hausen H (1981) Molecular cloning of viral DNA from human genital warts. J Virol 40:932–935

    PubMed  Google Scholar 

  • de Villiers E-M, Weidauer H, Otto H, zur Hausen H (1985) Papillomavirus DNA in human tongue carcinomas. Int J Cancer 36:575–578

    PubMed  Google Scholar 

  • de Villiers E-M (1994) Human pathogenic papillomaviruses: an update. In: zur Hausen H (ed) Curr Top Microbiol Immunol 86:1–12

  • Dürst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 80:3812–3815

    PubMed  Google Scholar 

  • Dürst M, Dzarlieva-Petrusevska RT, Boukamp P, Fusenig NE, Gissmann L (1987) Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1:251–256

    PubMed  Google Scholar 

  • Dürst M, Glitz D, Schneider A, zur Hausen H (1992) Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: analysis by in situ hybridization. Virology 189:132–140

    PubMed  Google Scholar 

  • Dyson N, Howley PM, Münger K, Harlow E (1989) The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937

    PubMed  Google Scholar 

  • Eliezri YD, Silverstein SJ, Nuovo GJ (1990) Occurrence of human papillomavirus type 16 DNA in cutaneous squamous and basal cell neoplasms. J Am Acad Dermatol 23:836–842

    PubMed  Google Scholar 

  • Euvrard S, Chardonnet Y, Pouteil-Noble C, Kanitakis J, Chignol MC, Thivolet J, Touraine JL (1993) Association of skin malignancies with various and multiple carcinogenic and non-carcinogenic human papiloomaviruses in renal transplant recipients. Cancer 72:2198–2206

    PubMed  Google Scholar 

  • Friedmann J-C, Levy J-P, Lasnaret J, Thomas M, Boiron M, Bernard J (1963) Induction de fibromes sous-cutanés chez le hamster doré par inoculation d'extrait acellulaires de papillomes bovins et leur transformation maligne par greffes isologues. C R Acad Sci (Paris) 257:2328–2331

    Google Scholar 

  • Ge R, Liu X, Ricciardi RP (1994) EIA oncogene of adenovirus-12 mediates trans-repression of MHC class I transcription in Ad5/Ad12 somatic hybrid transformed cells. Virology 203:389–392

    PubMed  Google Scholar 

  • Gissmann L, zur Hausen H (1976) Human papilloma viruses: physical mapping and genetic heterogeneity. Proc Natl Acad Sci USA 73:1310–1313

    PubMed  Google Scholar 

  • Gissmann L, Pfister H, zur Hausen H (1977) Human papilloma viruses (HPV): Characterization of four different isolates. Virology 76:569–580

    PubMed  Google Scholar 

  • Gissmann L, zur Hausen H (1980) Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 25:605–609

    PubMed  Google Scholar 

  • Gissmann L, Diehl V, Schultz-Coulon H, zur Hausen H (1982) Molecular cloning and characterization of human papillomavirus DNA from a laryngeal papilloma. J Virol 44:393–400

    PubMed  Google Scholar 

  • Grimmel M, de Villiers E-M, Pawlita M, Neumann C, zur Hausen H (1988) Characterization of a new human papillomavirus type (HPV 41) isolated from disseminated warts and the detection of closely related sequences in some squamous cell carcinomas. Int J Cancer 41:5–9

    PubMed  Google Scholar 

  • Halbert CL, Demers GW, Galloway DA (1991) The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol 65:473–478

    PubMed  Google Scholar 

  • Han R, Breitburd F, Marche PN, Orth G (1992) Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Nature 356:66–68

    PubMed  Google Scholar 

  • Hurlin PJ, Kaur P, Smith P, Perez-Reyes N, Blanton RA, McDougall JK (1991) Progression of human papillomavirus type 18 immortalized human keratinocytes to a malignant phenotype. Proc Natl Acad Sci USA 88:570–574

    PubMed  Google Scholar 

  • IARC Monograph on Evaluation of Carcinogenic Risks of Humans, Vol 59. Hepatitis viruses, IARC Lyon, 1994a

  • IARC Monograph on Evaluation of Carcinogenic Risks of Humans, Vol 61. Schistosomes, liver flukes andHelicobacter pylori, IARC Lyon, 1994b

  • Ikenberg H, Gissmann L, Gross G, Grussendorf-Conen E-I, zur Hausen H (1983) Human papillomavirus type 16 related DNA in genital Bowen's disease and in Bowenoid papulosis. Int J Cancer 32:563–564

    PubMed  Google Scholar 

  • Ito Y, Evans CA (1961) Induction of tumors in domestic rabbits with nucleic acid preparations from partially purified Shope papilloma virus and from extracts of the papillomas of domestic and cotton tail rabbits. J Exp Med 114:485–491

    Google Scholar 

  • Iwanowski D (1894) Über die Mosaikkrankheit der Tabakpflanze. Bull Acad Imp Sci St Petersburg 3(35):67–70

    Google Scholar 

  • Jablonska S, Millewski B (1957) Zur Kenntnis der Epidermodysplasia verruciformis Lewandowsky-Lutz. Dermatologica 115:1–22

    PubMed  Google Scholar 

  • Jablonska S, Dabrowski J, Jakubowicz K (1972) Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis. Cancer Res 32:583–589

    PubMed  Google Scholar 

  • Jarrett WFH (1980) Bracken fern and papilloma virus in bovine alimentar cancer. Br Med Bull 36:79–81

    PubMed  Google Scholar 

  • Kahn T, Schwarz E, zur Hausen H (1986) Molecular cloning and characterization of the DNA of a new human papillomavirus (HPV 30) from a laryngeal carcinoma. Int J Cancer 37:61–65

    PubMed  Google Scholar 

  • Kawashima M, Favre M, Obalek S, Jablonska S, Orth G (1990) Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses. J Invest Dermatol 95:537–542

    PubMed  Google Scholar 

  • Kirnbauer R, Booy F, Cheng N, Lowy DR, Schiller JT (1992) Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci USA 89:12 180–12 184

    Google Scholar 

  • Kirnbauer R, Hubbert NL, Wheeler CM, Becker TM, Lowy DR, Schiller JT (1994) A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. J Natl Cancer Inst 86:494–499

    PubMed  Google Scholar 

  • Lancaster WD, Olsen C (1978) Demonstration of two distinct classes of bovine papilloma virus. Virology 89:371–379

    Google Scholar 

  • Lane DP, Crawford LV (1979) T antigen is bound to a host protein in SV 40-transformed cells. Nature 278:261–263

    PubMed  Google Scholar 

  • Lewandowsky F, Lutz W (1922) Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). Arch Dermatol Syph (Berlin) 141:193–203

    Google Scholar 

  • Lin Y-L, Borenstein LA, Ahmed R, Wettstein FO (1993) Cottontail rabbit papillomavirus L1 protein-based vaccines: protection is achieved only with a full-length, nondenatured product. J Virol 67:4154–4163

    PubMed  Google Scholar 

  • Linzer DIH, Levine AJ (1979) Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17:43–52

    PubMed  Google Scholar 

  • Löning T, Ikenberg H, Becker J, Gissmann L, Hoepfner I, zur Hausen H (1985) Analysis of oral papillomas, leukoplakias and invasive carcinomas for human papillomavirus type related DNA. J Invest Dermatol 84:417–420

    PubMed  Google Scholar 

  • Lowy DR, Dvoretzky I, Shober R, Law M-F, Engel L, Howley PM (1980) In vitro tumorigenic transformation by a defined subgenomic fragment of bovine papilloma virus DNA. Nature 287:72–74

    PubMed  Google Scholar 

  • Lutz W (1946) A propos de l'epidermodysplasie verruciforme. Dermatologica 92:30–43

    Google Scholar 

  • Lutzner MA (1978) Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. Bull Cancer Paris 65:169–182

    PubMed  Google Scholar 

  • Lutzner MA, Orth G, Dutronquay V, Ducasse MF, Kreis H, Crosnier J (1983) Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lancet 2:422–424

    PubMed  Google Scholar 

  • Magelhaes O (1920) Verruga dos bovideos. Brasil-Medico 34:430–431

    Google Scholar 

  • Matsukura T, Sugase M (1995) Identification of genital human papillomaviruses in cervical biopsy specimen: segregation of specific virus types in specific clinicopathologic lesions. Int J Cancer 61:13–22

    PubMed  Google Scholar 

  • McFadyan J, Hobday F (1898) Note on the experimental “transmission of warts in the dog”. J Comp Pathol Ther 11:341–344

    Google Scholar 

  • Meisels A, Fortin R (1976) Condylomatous lesions of the cervix and vagina. I. Cytological patterns. Acta Cytol 20:505–509

    PubMed  Google Scholar 

  • Meisels A, Roy M, Fortier M, Morin C, Casas-Cordero M, Shah KV, Turgeon H (1981) Human papillomavirus infection of the cervix: the atypical condyloma. Acta Cytol 25:7–16

    PubMed  Google Scholar 

  • Moy RL, Eliezri YD, Nuovo GJ (1989) HPV DNA in periungual SSC. J Am Med Assoc 261:2669–2673

    Google Scholar 

  • Münger K, Phelps WC, Bubb V, Howley PM, Schlegel R (1989) The E6 and E7 genes of human papillomavirus type 16 are necessary and sufficient for transformation of primary human keratinocytes. J Virol 63:4417–4423

    PubMed  Google Scholar 

  • Muñoz N, Bosch FX, de Sanjose S, Tafur L, Izarzugaza I, Gili M, Viladiu P, Navarro C, Martos C, Asunce N (1992) The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in Colombia and Spain. Int J Cancer 52:743–749

    PubMed  Google Scholar 

  • Obalek S, Favre M, Szymanczyk J, Misiewicz J, Jablonska S, Orth G (1992) Human papillomavirus (HPV) types specific of epidermodysplasia verruciformis in warts induced by HPV3 or HPV3-related types in immunosuppressed patients. J Invest Dermatol 98:936–941

    PubMed  Google Scholar 

  • Olson C, Cook RH (1951) Cutaneous sarcoma-like lesions of the horse induced by the agent of bovine papilloma. Proc Soc Exp Biol Med 77:281–284

    PubMed  Google Scholar 

  • Olson C, Pamukcu AM, Brobst DF, Kowalczyk T, Satter EJ, Price JM (1959) A urinary bladder tumor induced by a bovine cutaneous papilloma agent. Cancer Res 19:779–782

    PubMed  Google Scholar 

  • Olson C, Pamukzu AM, Brobst DF (1965) Papilloma-like virus from bovine urinary bladder tumors. Cancer Res 25:840–849

    PubMed  Google Scholar 

  • Orth G, Favre M, Croissant O (1977) Characterization of a new type of human papillomavirus that causes skin warts. J Virol 24:108–120

    PubMed  Google Scholar 

  • Orth G, Jablonska S, Favre M, Jarzabek-Chorzelska M Rzesa G (1978) Characterization of two new types of HPV from lesions of epidermodysplasia verruciformis. Proc Natl Acad Sci USA 75:1537–1541

    PubMed  Google Scholar 

  • Orth G, Jablonska S, Jarzabek-Chorzelska M, Rzesa G, Obalek S, Favre M, Croissant O (1979) Characteristics of the lesions and risk of malignant conversion as related to the type of the human papillomavirus involved in epidermodysplasia verruciformis. Cancer Res 39:1074–1082

    PubMed  Google Scholar 

  • Pagano M, Dürst M, Joswig S, Draetta G, Jansen-Dürr P (1992) Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene 7:1681–1686

    PubMed  Google Scholar 

  • Pecoraro G, Lee M, Morgan D, Defendi V (1991) Evolution of in vitro transformation and tumorigenesis of HPV 16 and HPV 18 immortalized primary cervical epithelial cells. Am J Pathol 138:1–8

    PubMed  Google Scholar 

  • Pereira-Smith OM, Smith JR (1981) Expression of SV40 antigen in finite lifespan hybrids of normal and SV40-transformed fibroblasts. Somat Cell Genet 7:411–421

    PubMed  Google Scholar 

  • Pirisi L, Yasumoto S, Fellery M, Doninger JK, DiPaolo JA (1987) Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol 61:1061–1066

    PubMed  Google Scholar 

  • Preston DS, Stern RS (1992) Nonmelanoma cancers of the skin. New Engl J Med 327:1649–1662

    PubMed  Google Scholar 

  • Purdie KJ, Sexton CJ, Proby CM, Glover MT, Williams AT, Stables JN, Leigh IM (1993) Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus. Cancer Res 53:5328–5333

    PubMed  Google Scholar 

  • Rees J (1994) Genetic alterations in non-melanoma skin cancer. J Invest Dermatol 103:747–750

    PubMed  Google Scholar 

  • Rigoni-Stern D (1842) Fatti statistici relativi alle malatia cancerose. G Serv Prog Pathol Ther 2:507–517

    Google Scholar 

  • Rösl F, Dürst M, zur Hausen H (1988) Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine. EMBO J 7:1321–1328

    PubMed  Google Scholar 

  • Rösl F, Achtstetter T, Hutter K-J, Bauknecht T, Futterman G, zur Hausen H (1991) Extinction of the HPV 18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions. EMBO J 10:1337–1345

    PubMed  Google Scholar 

  • Rösl F, Lengert M, Albrecht J, Kleine K, Zawatzky R, Schraven B, zur Hausen H (1994) Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids. J Virol 68:2142–2150

    PubMed  Google Scholar 

  • Rotkin ID (1973) A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res 33:1353–1367

    PubMed  Google Scholar 

  • Rous P, Beard JW (1934) Carcinomatous changes in virus-induced papillomas of the skin of the rabbit. Proc Soc Exp Biol Med 32:578–580

    Google Scholar 

  • Rous P, Beard JW (1935) The progression to carcinoma of virusinduced rabbit papilloma (Shope). J Exp Med 62:523–548

    Google Scholar 

  • Rous P, Kidd JG (1938) The carcinogenic effect of a papillomavirus on the tarred skin of rabbits. I. Description of the phenomenon. J Exp Med 67:399–422

    Google Scholar 

  • Rous P, Friedewald WF (1944) The effect of chemical carcinogens on virus-induced rabbit papillomas. J Exp Med 79:511–537

    Google Scholar 

  • Rowson KEK, Mahy BWJ (1967) Human papova (wart) virus. Bacteriol Rev 31:110–131

    PubMed  Google Scholar 

  • Ruiter M, van Mullem PJ (1970) Behaviour of virus in malignant degeneration of skin lesions in epidermodysplasia verruciformis. J Invest Dermatol 54:324–331

    PubMed  Google Scholar 

  • Scheffner M, Werness BA, Huibregtse JM, Levine JM, Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129–1136

    PubMed  Google Scholar 

  • Schellender F, Fritsch F (1970) Epidermodysplasia verruciformis. Neue Aspekte zur Symptomatologie und Pathogenese. Dermatologica 140:251–259

    PubMed  Google Scholar 

  • Scheurlen W, Stremlau A, Gissmann L, Höhn D, Zenner HP, zur Hausen H (1986) Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma. Int J Cancer 38:671–676

    PubMed  Google Scholar 

  • Schiffman MH, Bauer HM, Hoover RN, Glass AG, Cadell DM, Rush BB, Scott DR, Sherman ME, Kurman RJ, Wacholder S (1993) Epidemiological evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst 85:958–964

    PubMed  Google Scholar 

  • Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, zur Hausen H (1985) Structure and transcription of human papillomavirus type 18 and 16 sequences in cervical carcinoma cells. Nature 314:111–114

    PubMed  Google Scholar 

  • Shamanin V, Glover M, Rausch C, Proby C, Leigh IM, zur Hausen H, de Villiers E-M (1994) Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients. Cancer Res 54:4610–4613

    PubMed  Google Scholar 

  • Shamanin V, zur Hausen H, Lavergne D, Proby C, Leigh I, Neumann C, Hamm H, Goos M, Haustein U-F, Jung E, Plewig G, Wolff H, de Villiers E-M (1995) HPV infections in non-melanoma skin cancers from renal transplant recipients and non-immunosuppressed patients, (submitted)

  • Shope RE (1933) Infectious papillomatosis of rabbits. J Exp Med 58:607–627

    Google Scholar 

  • Smits PHM, Smits HL, Minnaar R, Hemmings BA, Mayer-Jaekel RE, Schuurman R, van der Noordaa J, ter Schegget J (1992) The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11. EMBO J 11:4601–4606

    PubMed  Google Scholar 

  • Soler C, Chardonnet Y, Allibert P, Euvrard S, Schmitt D, Mandrand B (1993) Detection of mucosal human papillomavirus types 6/11 in cutaneous lesions from transplant recipients. J Invest Dermatol 101:286–291

    PubMed  Google Scholar 

  • Stark LA, Arends MJ, McLaren KM, Benton EC, Shahidullah H, Hunter JAA, Bird CC (1994) Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion. Brit J Cancer 69:222–229

    PubMed  Google Scholar 

  • Strauss MJ, Shaw EW, Bunting H, Melnick JL (1949) “Crystalline” virus-like particles from skin papillomas characterized by intranuclear inclusion bodies. Proc Soc Exp Biol Med 72:46–50

    PubMed  Google Scholar 

  • Stremlau A, Gissmann L, Ikenberg H, Stark M, Bannasch P, zur Hausen H (1985) Human pailloma virus type 16 related DNA in an anaplastic carcinoma of the lung. Cancer 55:1737–1740

    PubMed  Google Scholar 

  • Syrjänen K (1982) Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. Arch Geschwulstforsch 52:283–292

    PubMed  Google Scholar 

  • Syverton JT, Berry GP (1935) Carcinoma in the cottontail rabbit following spontaneous virus papilloma (Shope). Proc Soc Exp Biol Med 33:300–400

    Google Scholar 

  • Thomas M, Levy J-P, Tanzer J, Boiron M, Bernard J (1963) Transformation in vitro de cellules de peau de veau embryonnaire sous l'action d'extraits acellulaires de papillomes bovins. C R Acad Sci (Paris) 257:2155–2158

    Google Scholar 

  • Van der Leest RJ, Zachow KR, Ostrow RS, Bender M, Pass F, Faras AJ (1986) Human papillomavirus heterogeneity in 36 renal transplant recipients. Arch Dermatol 123:354–357

    Google Scholar 

  • Van Ranst M, Fuse A, Fiten P, Beuken E, Pfister H, Burk RD ( (1992) Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations Virology 190:587–596

    PubMed  Google Scholar 

  • von Knebel Doeberitz M, Oltersdorf T, Schwarz E, Gissmann L (1988) Correlation of modified human papillomavirus early gene expression with altered growth properties in C4-1, cervical carcinoma cells. Cancer Res 48:3780–3786

    PubMed  Google Scholar 

  • von Knebel Doeberitz M, Rittmüller C, zur Hausen H, Dürst M (1992) Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 antisense RNA. Int J Cancer 51:831–834

    PubMed  Google Scholar 

  • von Knebel Doeberitz M, Rittmüller C, Aengeneyndt F, Jansen-Dürr P, Spitkovsky D (1994) Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions J Virol 68:2811–2821

    PubMed  Google Scholar 

  • Werness BA, Levine AJ, Howley PM (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76–79

    Google Scholar 

  • White AE, Livanos EM, Tlsty TD (1994) Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev 8:666–677

    PubMed  Google Scholar 

  • Yabe Y, Okamoto T, Okmori S, Tanioku K (1969) Virus particles in epidermodysplasia verruciformis with carcinoma. Dermatologica 139:161–164

    PubMed  Google Scholar 

  • Yasumoto S, Burckhardt AL, Doninger J, DiPaolo JA (1986) Human papillomavirus type 16 DNA induced malignant transformation of NIH3T3 cells. J Virol 57:572–577

    PubMed  Google Scholar 

  • York IA, Roop C, Andrews DW, Ridell SR, Graham FL, Johnson DC (1994) A cytosolic Herpes simplex virus protein inhibits antigen presentation to CD8+T lymphocytes. Cell 77:525–535

    PubMed  Google Scholar 

  • Zeltner R, Borenstein LA, Wettstein FO, Iftner T (1994) Changes in RNA expression pattern during malignant progression of cottontail rabbit papillomavirus-induced tumors in rabbits. J Virol 68:3620–2630

    PubMed  Google Scholar 

  • Zerfass K, Schulze A, Spitkovsky D, Vousden K, Henglein B, Jansen-Dürr P (1995) S phase induction by the human papillomavirus 16 E7 oncogene reveals an activation cascade of cyclin E and cyclin A transcription. J. Virol. 69:6389–6399

    PubMed  Google Scholar 

  • zur Hausen H, Meinhof W, Scheiber W, Bornkamm GW (1974a) Attempts to detect virus-specific DNA sequences in human tumors. I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int J Cancer 13:650–656

    PubMed  Google Scholar 

  • zur Hausen H, Schulte-Holthausen H, Wolf H, Dörries K, Egger H (1974b) Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses. Int J Cancer 13:657–664

    PubMed  Google Scholar 

  • zur Hausen H (1976) Condylomata acuminata and human genital cancer. Cancer Res 36:530

    Google Scholar 

  • zur Hausen H (1977a) Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78:1–30

    PubMed  Google Scholar 

  • zur Hausen H (1977b) Cell-virus gene balance hypothesis of carcinogenesis. Behring Inst Mitt 61:23–30

    Google Scholar 

  • zur Hausen H (1980) The role of viruses in human tumors. Adv Cancer Res 33:77–107

    PubMed  Google Scholar 

  • zur Hausen H, (1986a) Intracellular surveillance of persisting viral infections: human genital cancer resulting from failing cellular control of papillomavirus gene expression. Lancet 2:489–491

    PubMed  Google Scholar 

  • zur Hausen H (1986b) Genital papillomavirus infections. In: Rigby PWJ, Wilkie NM (eds) Viruses and cancer. Cambridge University Press. Cambridge, UK, pp 83–90

    Google Scholar 

  • zur Hausen H (1989) Papillomaviruses in anogenital cancer: a model to understand the role of viruses in human cancers. Cancer Res 49:4677–4681

    PubMed  Google Scholar 

  • zur Hausen H (1991) Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9–13

    PubMed  Google Scholar 

  • zur Hausen H (1994) Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix. Lancet 343:955–957

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Dedicated to Professor Haruo Sugano on the occasion of his 70th birthday

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hausen, H.z. Roots and perspectives of contemporary papillomavirus research. J Cancer Res Clin Oncol 122, 3–13 (1996). https://doi.org/10.1007/BF01203067

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01203067

Keywords

Navigation