Summary
Adenoviruses recovered from the northern Stockholm area during 1987–1992 have been subjected to restriction endonuclease analysis. Adenoviruses of all subgenera (A-F) were represented and a considerable degree of serotype variation was seen, e.g. the rarely encountered subgenus A viruses were frequently isolated in the present study. Of 16 subgenus A isolates, Ad31 predominated with 12 strains which were equally distributed into the DNA-variants D2 and D7. Analysis of 38 Ad3 isolates revealed four DNA-variants: D1, D3, D10, and “Sto1”. The ten Ad7 isolates belonged all to the DNA-variant D5 of Ad7. Of 27 Ad1 strains, 11 belonged to D10, followed by the DNA-variants D4 and D7 with four strains each. Among Ad2 isolates, D2 or D2-like strains prevailed (23/28). Of six Ad5 strains, three belonged to the DNA-variant D2. The most notable subgenus D event was a nosocomial outbreak of keratokonjunctivitis due ot Ad19a. In addition, a collection of heterogenous subgenus D strains was detected, most of which untypable by RE-analysis. Among the six Ad4 isolates of subgenus E, both genomic clusters (p and a, respectively) of Ad4 were recognized. Concerning the clinical important subgenus F adenoviruses, only two strains of Ad40 were detected as compared to 12 strains of Ad41, all of which ascribed to the DNA-variant D12 of Ad41.
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Adrian T, Best B, Wigand R (1985) A proposal for naming adenovirus genome types, exemplified by adenovirus type 6. J Gen Virol 66: 2685–2691
Adrian T, Wadell G, Hierholzer JC, Wigand R (1986) DNA restriction analysis of adenovirus prototype 1 to 41. Arch Virol 91: 277–290
Adrian T, Wigand R, Richter J (1987) Gastroenteritis in infants, associated with a genome type of adenovirus 31 and with combined rotavirus and adenovirus 31 infection. Eur J Pediatr 146: 38–40
Adrian T, de Jong JC, van der Avoort HGAM, Wigand R (1988) Genome type analysis of adenovirus 37 isolates. J Med Virol 25: 77–83
Adrian T, Becker M, Hierholzer JC, Wigand R (1989a) Molecular epidemiology and restriction site mapping of adenovirus 7 genome types. Arch Virol 106: 73–84
Adrian T, Best B, Hierholzer JC, Wigand R (1989b) Molecular epidemiology and restriction site mapping of adenovirus type 3 genome types. J Clin Microbiol 27: 1329–1334
Adrian T, Wigand R, Knocke KW, Schäfer G, Grundmann M (1989c) Genome type analysis of adenoviruses: isolates from one year from the Hannover area. Arch Virol 105: 89–101
Adrian T, Sassinek J, Wigand R (1990) Genome type analysis of 480 isolates of adenovirus types 1, 2, and 5. Arch Virol 112: 235–248
Adrian T (1992) Genome type analysis of adenovirus type 4. Intervirology 34: 180–183
Bailey AS, Richmond SJ (1986) Genetic heterogeneity of recent isolates of adenovirus types 3, 4, and 7. J Clin Microbiol 24: 30–35
Brown M, Petric M, Middleton PJ (1984). Diagnosis of fastidious adenoviruses 40 and 41 in stool specimens. J Clin Microbiol 20: 334–338
Brown M (1990) Laboratory identification of adenoviruses associated with gastroenteritis in Canada from 1983 to 1986. J Clin Microbiol 28: 1525–1529
de Jong JC, Demazure M, Legrand-Quillien M-C, Le Lay G, Colin J, Wermenbol AG, Verweij-Uijterwaal MW, van der Avoort HGAM, Chastel C (1992) New developments in the molecular epidemiology of adenovirus 8 keratoconjunctivitis. J Med Virol 38: 102–107
de Jong JC, Bijlsma K, Wermenbol AG, Verweij-Uijterwaal MW, van der Avoort HGAM, Wood DJ, Bailey AS, Osterhaus ADME (1993) Detection, typing, and subtyping of enteric adenovirus 40 and 41 from fecal samples and observations of changing incidences of infections with these types and subtypes. J Clin Microbiol 31: 1562–1569
Desmyter J, De Jong JC, Slaterus KW, Verlaeckt H (1974) Keratoconjunctivitis caused by adenovirus type 19. Br Med J 4: 406
Hierholzer JC, Guyer B, O'Day DM, Schaffner W (1974): Adenovirus type 19 keratoconjunctivitis. N Engl J Med 290: 1436
Hierholzer JC (1989) Diagnostic procedures for viral, rickettsial and chlamydial infections. In: Schmidt NJ, Emmons RW (eds) Adenoviruses. American Public Health Association, Washington pp 219–264
Hierholzer JC, Stone YO, Broderson JR (1991) Antigenic relationships among the 47 human adenoviruses determined in reference horse antisera. Arch Virol 121: 179–197
Hierholzer JC (1992) Adenoviruses in the immunocompromised host. Clin Microbiol Rev 5: 262–274
Johansson ME, Brundin N, Adamson L, Grillner L, Landqvist M, Thörner Å, Zweygberg Wirgart B (1989) Characterization of two genome types of adenovirus type 31 isolated in Stockholm during 1987. J Med Virol 28: 63–68
Johansson ME, Brown M, Hierholzer JC, Thörner Å, Ushijma H, Wadell G (1991) Genome analysis of adenovirus type 31 strains from immunocompromised and immunocompetent patients. J Infect Dis 163: 293–299
Johansson ME, Ahrel-Andersson M, Gudnadottir S (1993) Molecular epidemiology of adenoviruses isolated in Iceland during 1980–1990. J Virol Methods 42: 193–206
Kajon AE, Suarez VS, Avendano LF, Hortal M, Wadell G (1993) Genome type analysis of South American adenoviruses of subgenus C collected over a 7-year period. Arch Virol 132: 29–35
Kemp MC, Hierholzer JC, Cabradilla CP, Obijeski JF (1983) The changing etiology of epidemic keratoconjunctivitis: antigenic and restriction enzyme analyses of adenovirus types 19 and 37 isolated over a 10-year period. J Infect Dis 148: 24–32
Kemp MC, Hierholzer JC (1986) Three adenovirus type 8 genome types defined by restriction enzyme analysis: prototype stability in geographically separated populations. J Clin Microbiol 23: 469–474
Li Q-G, Wadell G (1986) Analysis of 15 different genome types of adenovirus 7, isolated on five continents. J Virol 60: 331–335
Li Q-G, Wadell G (1988) Comparison of 17 genome types of adenovirus type 3 identified among strains recovered from six continents. J Clin Microbiol 26: 1009–1015
Li Q-G, Wadell G (1988) The degree of genetic variability among adenovirus type 4 strains isolated from man and chimpanzee. Arch Virol 101: 65–67
Li Q-G, Hambreus J, Wadell G (1991) Genetic relationship between thirteen genome types of adenovirus 11, 34, and 35 with different tropism. Intervirology 32: 338–350
O'Donnell B, Bell E, Payne SB, Mautner V, Desselberg U (1986) Genome analysis of species 3 adenoviruses isolated during summer outbreaks of conjunctivitis and pharyngoconjunctival fever in the Glasgow and London areas in 1981. J Med Virol 18: 213–227
Schmitz H, Wigand R, Heinrich W (1983) World-wide epidemiology of human adenovirus infections. Am J Epidemiol 117: 455–466
Schnurr D, Dondero ME (1993) Two new candidate adenovirus serotypes. Intervirology 36: 79–83
Shinozaki T, Araki K, Fujita Y, Kobayashi M, Tajima T, Abe T (1991) Epidemiology of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children in the Tokyo area. Scand J Infect Dis 23: 543–547
Thörner Å, Johansson ME, Hierholzer JC (1992) Restriction endonuclease patterns of adenovirus type 12 and 18. J Virol Methods 39: 101–109
Wadell G, De Jong JC (1980) Restriction endonucleases in identification of a genome type of adenovirus 19 associated with keratokonjunctivitis. Infect Immun 27: 292–296
Wadell G (1984) Molecular epidemiology of human adenoviruses. Curr Top Microbiol Immunol 110: 191–220
Van der Avoort HGAM, Adrian T, Wigand R, Wermenbol AG, Zomerdijk TPL, De Jong JC (1986) Molecular epidemiology of adenovirus type 21 in the Netherlands and the Federal Republic of Germany from 1960 to 1985. J Clin Microbiol 24: 1084–1088
Van der Avoort HGAM, Wermenbol AG, Zomerdijk TPL, Kleijne JAFW, Van Asten JAAM, Jensma P, Osterhaus ADME, Kidd AH, De Jong JC (1989) Characterization of fastidious adenovirus types 40 and 41 by DNA restriction enzyme analysis and by neutralizing monoclonal antibodies. Virus Res 12: 139–158
Wigand R, Adrian T (1991) A rational system for classifying and denominating adenovirus genome types. Virus Res 142: 47–56
Willcocks MM, Carter MJ, Laidler FR, Madeley CR (1988) Restriction enzyme analysis of feacal adenoviruses in Newcastle upon Tyne. Epidemiol Infect 101: 445–458
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Johansson, M.E., Andersson, M.A. & Thörner, P.Å. Adenoviruses isolated in the Stockholm area during 1987–1992: restriction endonuclease analysis and molecular epidemiology. Archives of Virology 137, 101–115 (1994). https://doi.org/10.1007/BF01311176
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DOI: https://doi.org/10.1007/BF01311176