Summary
Background
Adenosquamous carcinoma of the pancreas most probably represents squamous metaplasia of an adenocarcinoma. Metastases are typically an admixture of both elements, but more frequently, adnocarcinoma.
Methods
A review of 102 pancreaticoduodenectomies for masses of the head of the pancreas done between 1994 and 1998 revealed two patients with adenosquamous carcinoma of the pancreas.
Results
Both patients underwent successful pancreaticoduodenctomy, but were found to have nodal metastasis. One patient lived 13 mo and the other lived 14 mo with both dying from metastatic disease.
Conclusion
Adenosquamous carcinoma of the pancreas is a rare tumor, and because its presentation, clinical features, and course are identical to adenocarcinoma of the pancreas, it should be considered in the differential diagnosis for any mass of the head of the pancreas. Survival is poor for these patients. In this series, it was 13 and 14 mo, respectively.
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References
Sommers SC, Meissner WA. Unusual carcinomas of the pancreas.Arch Pathol 1954; 58: 101–111.
Cihak RW, Taketsugu K, Steer A. Adenoacanthoma (adenosquamous carcinoma) of the pancreas.Cancer 1972; 28: 1133–1140.
Weitzner S. Adenoacanthoma of the pancreas. Report of four cases and literature review.Am Surg 1978; April: 206–209.
Ishikawa O, Matsui Y, Aoki I, Iwanaga T, Terasawa T, Wada A. Adenosquamous carcinoma of the pancreas: A clinicopathologic study and report of three cases.Cancer 1980; 46: 1192–1196.
Yamaguchi K, Enjoji M. Adenosquamous carcinoma of the pancreas: A clinicopathologic study.J Surg Oncol 1991; 47: 109–116.
Herzheimer G, Leterologe cancroide.Beitr Pathol Anat 1907; 41: 348–412.
Kovi J. Adenosquamous carcinoma of the pancreas: A light and electron microscopic study.Ultrastruc Pathol 1982; 3: 17–23.
Beyer KL, Mdarshal JB, Metzler MH, Poulter JS, Seger RM, Diaz-Arias AA. Squamous cell carcinoma of the pancreas: Report of an unusual case and review of the literature.Dig Dis Sci 1992; 37(2): 312–318.
Sears HF, Young K, Strawitz J. Squamous cell carcinoma of the pancreas.J Surg Oncol 1980; 14: 261–265.
Solcia E, Capella C, Kloppel G.Atlas of Tumor Pathology, Tumors of the Pancreas. Rosai J, ed. AFIP, Washington, DC, 1997, p. 88.
Motojima K, Tomioka T, Kohara N, Tsunoda T, Kanematsu T. Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas.J SurgOncol 1992; 49: 58–62.
Makiyama K, Takuma K, Zea-Iriarte WL, Ikuno N, Kawatomi M, Mori N, et al. Adenosquamous carcinoma of the pancreas.J Gastroenterol 1995; 30: 798–802.
Campman SC, Fajardo MA, Rippon MB, Kraegel SA, Ruebner BH. Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas.J Surg Oncol 1997; 64: 159–162.
O'Connor DS, Ruchman RB. Adenosquamous carcinoma of the pancreas.NJ Med 1993; 90: 527–529.
Smit W, Mathy JP, Donaldson E. Pancreatic cytology and adenosquamous carcinoma of the pancreas.Pathology 1993; 25: 420–422.
Wilchynksi SP, Valente PT, Atkinson BF. Cytodiagnosis of adenosquamous carcinoma of the pancreas: Use of intraoperative fine needle aspiration.Acta Cytologica 1984; 28(6): 733–736.
Shariff S., Thomas JA. Adeno-squamous carcinoma pancreas, a case report with literature review.Indian J Pathol Microbiol 1989; 32(1): 62–65.
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Aranha, G.V., Yong, S. & Olson, M. Adenosquamous carcinoma of the pancreas. Int J Gastrointest Canc 26, 85–91 (1999). https://doi.org/10.1007/BF02781735
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DOI: https://doi.org/10.1007/BF02781735