Abstract
A new concept of IgG subclass such as IgG4-related systemic disease including autoimmune pancreatitis, characterized by a high-serum IgG4 level, has been proposed. Our aim was to investigate serum IgG subclass levels in rheumatoid arthritis (RA). IgG subclass levels of sera from 72 patients with rheumatoid arthritis were determined by immunonephelometric assay. The patients were divided into two groups according to clinical activity of the disease: active disease and remission. The sera from 45 normal controls were also measured. All statistical analyses were carried out with SPSS software version 13.0. We found a significant increase of all the four IgG subclass concentrations in sera of patients with RA compared to those of the controls (P < 0.001). When the patients were divided according to clinical activity, the IgG subclass concentrations were similar between the two groups (P > 0.05). Our data suggest that besides IgG1, IgG2 and IgG3, IgG4 may involve in the pathogenesis of the disease.
References
Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K (2001) High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344:732–738
Chapuy-Regaud S, Nogueira L, Clavel C, Sebbag M, Vincent C, Serre G (2005) IgG subclass distribution of the rheumatoid arthritis-specific autoantibodies to citrullinated fibrin. Clin Exp Immunol 139:542–550
Martini A, Plebani A, Ravelli A, Avanzini MA, Jefferis R, Zonta L, Notarangelo LD, Ugazio AG, Burgio R (1986) IgG subclass serum levels in juvenile chronic arthritis. Ann Rheum Dis 45:400–404
Shakib F, Stanworth DR (1976) IgG subclass composition of rheumatoid arthritic sera and joint fluids. Ann Rheum Dis 35:263–266
Pressac M, Allouche F, Circaud R, Aymard P (1995) Evaluation of human IgG subclass assays on Beckman array. Ann Clin Biochem 32(Pt 3):281–288
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324
Fransen J, Langenegger T, Michel BA, Stucki G (2000) Feasibility and validity of the RADAI, a self-administered rheumatoid arthritis disease activity index. Rheumatology (Oxford) 39:321–327
Martini A, Avanzini MA, Ravelli A, Zonta L, Plebani A, de Benedetti F, Burgio RG (1989) Variation of serum IgG subclass concentrations with disease activity in juvenile chronic arthritis. Ann Rheum Dis 48:582–585
Ravetch JV, Bolland S (2001) IgG Fc receptors. Annu Rev Immunol 19:275–290
Engelmann R, Brandt J, Eggert M, Karberg K, Krause A, Neeck G, Mueller-Hilke B (2008) IgG1 and IgG4 are the predominant subclasses among auto-antibodies against two citrullinated antigens in RA. Rheumatology (Oxford) 47:1489–1492
Cohen PL, Cheek RL, Hadler JA, Yount WJ, Eisenberg RA (1987) The subclass distribution of human IgG rheumatoid factor. J Immunol 139:1466–1471
Mihai S, Chiriac MT, Herrero-Gonzalez JE, Goodall M, Jefferis R, Savage CO, Zillikens D, Sitaru C (2007) IgG4 autoantibodies induce dermal-epidermal separation. J Cell Mol Med 11:1117–1128
Kawa S, Kitahara K, Hamano H, Ozaki Y, Arakura N, Yoshizawa K, Umemura T, Ota M, Mizoguchi S, Shimozuru Y, Bahram S (2008) A novel immunoglobulin - immunoglobulin interaction in autoimmunity. PLoS ONE 3:e1637
van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martínez-Martínez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, De Baets MH, van de Winkel JG, Aalberse RC, Parren PW (2007) Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317:1554–1557
Aalberse RC, van der Gaag R, van Leeuwen J (1983) Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130:722–726
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We thank professor Jian Guo and professor Zhi-Xian Xie of Beijing Hospital for their assistance.
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Lin, G., Li, J. Elevation of serum IgG subclass concentration in patients with rheumatoid arthritis. Rheumatol Int 30, 837–840 (2010). https://doi.org/10.1007/s00296-009-1330-8
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DOI: https://doi.org/10.1007/s00296-009-1330-8