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Hepatocellular carcinoma associated with focal nodular hyperplasia

Report of a case with clonal analysis

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Abstract.

We describe a hepatocellular carcinoma partially surrounded by focal nodular hyperplasia in a 65-year-old female patient. In order to clarify the relationship of the hepatocellular carcinoma and the adjacent focal nodular hyperplasia, clonal analysis was conducted. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome-linked androgen receptor gene (HUMARA). The allelic bands from the amplification of the focal nodular hyperplasia and of the hepatocellular carcinoma showed a significant reduction in the intensity of one of the two alleles as compared with two alleles of equal intensity in the buff coat after HhaI digestion, which indicated that these two parts were monoclonal. However, the inactivated allele in the focal nodular hyperplasia and that in the hepatocellular carcinoma were not identical. Therefore, the focal nodular hyperplasia and hepatocellular carcinoma probably derived from the clonal expansion of two different clones.

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Authors and Affiliations

  1. Department of Pathology, Chang Gung Memorial Hospital, 5 Fu Shin Street, Kwei San, Tao Yuan, Taiwan, Taiwan

    Tse-Ching Chen & Kwai-Fong Ng

  2. Department of Zoology, National Taiwan University, Taipei, Taiwan, Taiwan

    Tze-Bin Chou

  3. Department of Public Health, Chang Gung University, Tao Yuan, Taiwan, Taiwan

    Ling-Ling Hsieh

  4. Human Molecular Genetics Laboratory, Chang Gung Memorial Hospital, Tao Yuan, Taiwan, Taiwan

    Yah-Huei Chou

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  1. Tse-Ching Chen
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  2. Tze-Bin Chou
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  3. Kwai-Fong Ng
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  4. Ling-Ling Hsieh
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  5. Yah-Huei Chou
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Chen, TC., Chou, TB., Ng, KF. et al. Hepatocellular carcinoma associated with focal nodular hyperplasia. Virchows Arch 438, 408–411 (2001). https://doi.org/10.1007/s004280000348

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  • DOI: https://doi.org/10.1007/s004280000348

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