Skip to main content
Log in

Genetic variability of hexon loops 1 and 2 between seven genome types of adenovirus serotype 7

  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary.

 In order to understand the evolutionary relationships between different genome types of adenovirus serotype 7, the nucleotide sequences of the hexon loops 1 and 2 from seven genome types have been determined. Their amino acid sequences comprising 473 to 476 residues were consequently analysed. The pairwise comparison of the sequences from seven genome types revealed the existences of two genome type clusters (GTCs). GTC1 includes Ad7p and Ad7p1, and GTC2 contains Ad7b, Ad7c, Ad7d, Ad7g and Ad7h. The amino acid similarity was 98.3–99.8% within a cluster and 93.0–94.5% between two clusters. However, the average amino acid similarity among 16 different human adenovirus serotypes was only 65% with two exceptions, 92.7% between Ad4 and Ad16, and 86.8% between Ad3 and Ad7. Two variable regions were found in the loops 1 and 2. A deletion of nine nucleotides was detected in the variable region 1 of all members of GTC2. According to the alignment of nucleotide sequences, two short direct repeats were found at the deletion junctions, indicating that GTC2 may be derived from GTC1 by illegitimate recombination. In variable region 2, the substitution from 443Leu (Ad7b) to Gln (Ad7d) dramatically affected the hydropathic characters of this region. The region surrounding 443Leu (Ad7b) manifested hydrophobicity whereas the region surrounding Gln (Ad7d) manifested hydrophilicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received June 22, 1998 Accepted April 19, 1999

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, QG., Wadell, G. Genetic variability of hexon loops 1 and 2 between seven genome types of adenovirus serotype 7. Arch. Virol. 144, 1739–1749 (1999). https://doi.org/10.1007/s007050050701

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s007050050701

Navigation