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Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

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Abstract

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

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Acknowledgments

This work was supported in part by the Kenneth D. Müller Professorship (AEN), National Cancer Institute Specialized Program of Research Excellence (SPORE) grant in head and neck cancer and the National Cancer Institute grant CA-16672.

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Correspondence to Adel K. El-Naggar.

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Bell, D., Zhao, YJ., Rao, P.H. et al. Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue. Head and Neck Pathol 1, 165–168 (2007). https://doi.org/10.1007/s12105-007-0030-5

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  • DOI: https://doi.org/10.1007/s12105-007-0030-5

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