Clinical studyAssociation between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus
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Cardiac Involvement in Systemic Lupus Erythematosus
2017, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :Ischemia due to atherosclerosis, although occurring earlier in SLE patients than in the normal population, affects more frequently older SLE patients, with long-standing disease, long period of corticosteroid intake, and, usually, quiescent disease at the time of the cardiovascular event. Ischemic cardiopathy could be due to APS (Asherson et al., 1989; Murpy and Leach, 1989; Leung et al., 1990a,b; MacGregor et al., 1992; Kattwinkel et al., 1992), and in this case could develop at any age and in any stage of the disease course. Urowitz et al. (1976) described a bimodal distribution of the causes of death in SLE: an “early” peak due to SLE severity/activity or infections and a “late” peak due to atherosclerotic CAD; this trend has been confirmed in other studies too (Rubin et al., 1985; Abu-Shakra et al., 1995).
Cardiac Involvement in the Antiphospholipid Syndrome
2017, Handbook of Systemic Autoimmune DiseasesPrevalence and predictors of valvular heart disease in patients with systemic lupus erythematosus
2016, Autoimmunity ReviewsCitation Excerpt :In this study we found a one-in-four prevalence of significant valvulopathy in patients with SLE. In previous studies, the prevalence of VHD has ranged between 12% and 73%; the different criteria to define valvular lesions and the different diagnostic methods may account for the large variability in the results [1–4,21–24,27–34]. Despite the fame of verrucous endocarditis described by Libman and Sacks [5], most echocardiographic studies have shown that thickening is by large the most frequent valvular lesion [4,15,16,22,24,25].
Evolution of cardiac dysfunction in patients with antiphospholipid antibodies and/or antiphospholipid syndrome: A 10-year follow-up study
2014, Seminars in Arthritis and RheumatismCitation Excerpt :In contrast, other studies did not observe any difference among the above groups [19,42]. An association between aPL and valve abnormalities was described by most transthoracic echocardiography studies examining SLE patients with and without aPL [5,6,11,12,33,43,44], while data from the transesophageal ehocardiographic studies did not support this association [4,33,45,46] (Supplementary Table 2). The valvular disease was persistent or progressive over time in most prospective echocardiographic studies in SLE [3,10,11].