Elsevier

Clinical Biochemistry

Volume 27, Issue 5, October 1994, Pages 319-332
Clinical Biochemistry

Role of chemopreventers in human diet

https://doi.org/10.1016/0009-9120(94)00039-5Get rights and content

Abstract

Recent research has confirmed that many common foods contain nonnutritive components that may provide protection against chronic disease including some forms of cancer. These naturally occurring compounds, which possess anticarcinogenic and other beneficial properties, are referred to as chemopreventers. The predominant mechanism of their protective action is due to their antioxidant activity and the capacity to scavenge free radicals. Among the most investigated chemopreventers are some vitamins, plant polyphenols, flavonoids, catechins, and some components in spices. The majority of chemopreventers are available in and consumed from vegetables, fruits, grains, and tea. Various naturally occurring chemicals in garlic, soybeans, tea, and red wine appear to be responsible for the beneficial effect of these commodities on several chronic diseases. This article will review some recent studies in the search for the beneficial effects of dietary chemopreventers on human health.

References (201)

  • G. Hocman

    Chemoprevention of cancer: Selenium

    Intl J Biochem

    (1988)
  • H.P. Lee et al.

    Dietary effects on breast-cancer risk in Singapore

    Lancet

    (1991)
  • M. Nagabhushan et al.

    Anticarcinogenic action of diallyl sulfide in hamster buccal pouch and forestomach

    Cancer Lett

    (1992)
  • Y.S. Zhang et al.

    Antimutagenic effect of garlic (Allium sativum L.) on 4NQO-induced mutagenesis in Escherichia coli WP2

    Mutat Res

    (1989)
  • N.R. Shenoy et al.

    Inhibitory effect of diet related sulphydryl compounds on the formation of carcinogenic nitrosamines

    Cancer Lett

    (1992)
  • A.K. Jain et al.

    Can garlic reduce levels of serum lipids? A controlled clinical study

    Am J Med

    (1993)
  • R. Apitz-Castro et al.

    Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation

    Thromb Res

    (1992)
  • J. Harenberg et al.

    Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia

    Atherosclerosis

    (1988)
  • H. Fujiki et al.

    Anticarcinogenic effects of (−)epigallocatechin gallate

    Prev Med

    (1992)
  • H. Hayatsu et al.

    Suppression of genotoxicity of carcinogens by (−)epigallocatechin gallate

    Prev Med

    (1992)
  • T. Kada et al.

    Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor

    Mutat Res

    (1985)
  • R. Doll et al.

    The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today

    J Natl Cancer Inst

    (1981)
  • Diet, Nutrition and Cancer

    (1982)
  • D.F. Birt et al.

    Chemoprevention by nonnutrient components of vegetables and fruits

  • L.W. Wattenberg

    Inhibition of carcinogenesis by minor dietary constituents

    Cancer Res

    (1992)
  • M.A. Morse et al.

    Cancer chemoprevention: Principles and prospects

    Carcinogenesis

    (1993)
  • S.M. Lippman et al.

    Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis

    Cancer Res

    (1994)
  • G. Block et al.

    Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

    Nutr Cancer

    (1992)
  • H.L. Newmark

    Plant phenolic compounds as inhibitors of mutagenesis and carcinogenesis

  • J.H. Weisburger

    Mutagenic, carcinogenic, and chemopreventive effects of phenols and catechols. The underlying mechanisms

  • R.K. Harris et al.

    Assays for potentially anticarcinogenic phytochemicals in flaxseed

    Cereal Foods World

    (1993)
  • T. Ulbricht

    Health and food industry—What lies ahead—Nutriceuticals

    Food Policy

    (1993)
  • L.W. Wattenberg

    Chemoprevention of cancer

    Cancer Res

    (1985)
  • T. Fuleki

    Vineland vistas

    The Grower

    (1993)
  • M.J. Thun et al.

    Risk factors for fatal colon cancer in a large prospective study

    J Natl Cancer Inst

    (1992)
  • M.K. Shigenaga et al.

    Oxidants and mitogenesis as causes of mutation and cancer: The influence of diet

  • L.E. Hansson et al.

    Diet and risk of gastric cancer—a population-based case-control study in Sweden

    Int J Cancer

    (1993)
  • R.G. Ziegler et al.

    Does β-carotene explain why reduced cancer risk is associated with vegetable and fruit intake?

    Cancer Res

    (1992)
  • S. Sugie et al.

    Inhibitory effects of benzyl isothiocyanate and benzy thiocyanate on dimenthylnitrosamine-induced hepatocarcinogenesis in rats

    Jpn J Cancer Res

    (1993)
  • Y. Zhang et al.

    A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure

  • W.C. Willett

    Diet and health: What should we eat?

    Science

    (1994)
  • P.A. Vargas et al.

    Primary prevention of colorectal cancer through dietary modification

    Cancer

    (1992)
  • J. Ebata et al.

    Inhibitory effects of dietary leafy vegetables on mutagens and active oxygens

  • R.H. Dashwood et al.

    Mechanisms of anticarcinogenesis by indol-3-carbinol: Detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1

    Carcinogenesis

    (1988)
  • T. Tanaka et al.

    Inhibitory effect of sinigrin and indol-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats

    Carcinogenesis

    (1990)
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