Strongyloides stercoralis: Histopathology of uncomplicated and hyperinfective strongyloidiasis in the Mogolian gerbil, a rodent model for human strongyloidiasis
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Treatment with nitric oxide donors diminishes hyperinfection by Strongyloides venezuelensis in mice treated with dexamethasone
2015, Acta TropicaCitation Excerpt :DXM is related to the increase of parasite viability in the host but the presence of two separated peaks in egg emission could be due to autoinfection. Our results are comparable to those of other studies using dexamethasone to obtain an experimental model of Strongyloides hyperinfection in mice (Machado et al., 2011), gerbils (Kerlin et al., 1995) and using a non-human primates (de Melo et al., 2012). The novel aspect of this study is that we found that treatment with aminoguanidine in the context of immunosuppression by dexamentasone induces active hyperinfection by S. venezuelensis with fecal egg outputs and burdens of, larvae in the lungs and parasitic females in the intestines, that surpassing those in infected hosts treated with dexamethasone only.
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