Undifferentiated carcinomas of the major salivary glands

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Abstract

Undifferentiated salivary carcinomas are defined as primary epithelial nelignant neoplasms that are devoid of any phenotypic expression by light microscopy that would allow them to be otherwise classified. A clinicopathologic study of sixteen so-defined carcinomas of the major salivary glands is presented. The carcinomas are unquestionably high-grade malignant neoplasms. Ten of the sixteen patients were dead because of their disease within 412 years of histologic diagnosis. Cell size and ultrastructural features have little bearing on prognosis. The single most important clinicopathologic factor relating to patient outcome is size of the primary neoplasm. All patients with carcinomas larger than 4 cm died, and these carcinomas had nearly two times the incidence of perineural invasion, extrasalivary extension, and locoregional failure of control.

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      We also performed surgery as the main therapy. We did not perform additional radiotherapy or chemo-radiotherapy because we judged our case as non-invasive based on previous studies that reported the negative surgical margins led to a good prognosis [11], and the effect of radiotherapy was unclear according to reported cases [7–10]. Fourteen months later, he is free of tumors.

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    This study was supported, in part, by a grant from the Caduceus Foundation, New York, New York.

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