Original contributionNecrotizing funisitis: A study of 45 cases☆
References (24)
- et al.
Subacute necrotizing funisitis: A variant of cord inflammation with a high rate of perinatal infection
J Pediatr
(1974) - et al.
Placental inflammation and infection. A prospective bacteriologic and histologic study
Am J Obstet Gynecol
(1966) - et al.
The value of umbilical cord histology in the management of potential perinatal infection
J Pediatr
(1970) - et al.
Intrauterine bacterial infection of the newborn infant: Frozen sections of the cord as an aid to early detection
J Pediatr
(1959) - et al.
Relative placental weight in congenital syphilis
Placenta
(1990) - et al.
Congenital syphilis and necrotizing funisitis
JAMA
(1989) - et al.
Necrotizing funisitis. 60 cases
Lab Invest
(1986) Pathologisch-anatomische Veränderungen in der Nachgeburt bei Syphilis
Beitr Pathol Anat
(1905)Die syphilitischen Veränderungen in der Nabelschnur
Arch Gynakol
(1903)Die Veränderungen an Placenta, Nabelschnur, und Eihäuten bei Syphilis und ihre Beziehungen zur Spirochäta pallida
Z Geburtschilfe Gynakol
(1907)
Umbilical cord sclerosis as an indicator of congenital syphilis
J Clin Pathol
Degeneration and calcification of the umbilical cord
Obstet Gynecol
Cited by (44)
Necrotizing funisitis associated with Ureaplasma urealyticum infection: A clinicopathologic analysis of 14 cases
2022, PlacentaCitation Excerpt :Necrotizing funisitis is characterized as a distinct morphologic lesion with a crescent of necrosis, often calcified, between the surface of the umbilical cord and umbilical vessel walls that is not present in the usual funisitis (acute umbilical cord inflammation) [1–3].
Necrotizing funisitis is an indicator that intra-amniotic inflammatory response is more severe and amnionitis is more frequent in the context of the extension of inflammation into Wharton's jelly
2021, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Unfortunately, although previous several classifications [5,6,11,15] included NF, these studies had limitations in the classification for the progression of inflammation in UC as follows: 1) the presence or absence of inflammation in WJ was not considered [5,6]; and 2) only NF, but not inflammation in umbilical vessels and WJ, was focused [11,15]. In addition to these limitations, they did not examine IAIR [5,6,11,15]. Notably, our current study demonstrated that NF is the most advanced stage in the inflammation of UC based on the finding that the surrogate markers for FIR (i.e., IAIR and amnionitis) are continuously increased with the progression of inflammation in the whole subdivisions of UC (i.e., stage-1, umbilical phlebitis only; stage-2, involvement of at least one UA and either the other UA or UV without extension into WJ; stage-3, the extension of inflammation into WJ without NF; and stage-4, the extension of inflammation into WJ with NF).
Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis patterning
2021, PlacentaCitation Excerpt :Staging is principally determined by the distribution of polymorphonuclear leukocytes. Stage 1 of the fetal inflammatory response includes chorionic vasculitis or umbilical phlebitis, stage 2 refers to umbilical phlebitis with one or more arteritis lesions, and stage 3 represents the so-called necrotizing funisitis [8,9]. In contrast, grading depends on the density of polymorphonuclear leukocytes.
Perinatal Infections
2018, Diagnostic Pathology of Infectious DiseaseSyphilis (Treponema pallidum)
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
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Presented in part at the American Society of Clinical Pathologists/College of American Pathologists Fall Meeting, New Orleans, LA, September 1991.