Original contributionDesmin and neural marker expression in mesothelial cells and mesotheliomas
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Malignant mesothelioma in situ: diagnostic and clinical considerations
2020, PathologyCitation Excerpt :It was recognised that cytological atypia was variable, and that some cases would only be diagnosable by ancillary techniques, and the diagnosis was not advised to be made in the absence of invasion by histological, radiological or thoracoscopic means.10 Various markers or combinations of markers have been proposed, including limited strong linear labelling for epithelial membrane antigen (EMA) and loss of desmin11,12 with silver labelling of nucleolar organising regions (AgNORs),8 defined as in excess of the areas found in proven benign reactive mesothelial proliferations, as well labelling for Glut1, CD146 and IMP3.13 However, these techniques could be subjective and were not infallible.14
Mesenchymal chondrosarcomas showing immunohistochemical evidence of rhabdomyoblastic differentiation: a potential diagnostic pitfall
2018, Human PathologyCitation Excerpt :In skeletal muscle, desmin is localized to the Z-zone between the myofibrils, where it functions as a binding material for the contractile apparatus. Although it is well known that desmin is a highly (~100%) sensitive marker of rhabdomyosarcomas, it is less widely appreciated that desmin expression is by no means specific for skeletal (or smooth) muscle differentiation, and may be present in Ewing sarcoma [17], desmoplastic small round cell tumors [18], mesothelial tumors [19], tenosynovial giant cell tumors [20], ossifying fibromyxoid tumors [21], angiomatoid fibrous histiocytomas [22], and melanoma [23]. Desmin expression, by itself, is thus not necessarily indicative of skeletal muscle differentiation in mesenchymal chondrosarcoma.
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