Cell
Volume 79, Issue 3, 4 November 1994, Pages 393-395
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Flip-flop: The transmembrane translocation of lipids

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    Second, the flippase model in which the hydrophobic parts of the drugs allow their rapid introduction in the membrane. The hydrophilic parts inhibit rapid flipping of the drug to the inner leaflet of the membrane, delaying entry into the cell and consequently lowering the effective drug concentration inside the cell [101,102]. And third, the vacuum cleaner model has been suggested in which substrates, detected in the lipid bilayer, are removed from the cell before reaching the cytoplasm [103].

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