Extent, distribution, and mammographic/ histological correlations of breast ductal carcinoma in situ

doi:10.1016/0140-6736(90)90747-S

The Lancet

Volume 335, Issue 8688, 3 March 1990, Pages 519-522

https://doi.org/10.1016/0140-6736(90)90747-S Get rights and content

Abstract

To assess the potential of breast-conserving treatment for ductal carcinoma in situ (DCIS), 82 mastectomy specimens were studied by Egan's serial subgross method. 42 (51%) of the tumours were larger than 50 mm and only 12 (15%) were smaller than 20 mm; the size distribution was not affected by the mode of detection (mammography 52 cases, clinical examination 30). All but 1 case showed only 1 region of tumour. 66% of tumours involved one breast quadrant, 23% extended over more than one quadrant, and 11% were centrally located. Mammographic estimates, based on the extent of microcalcifications, frequently underestimated the histological size of tumours, the extent of the discrepancy being related to the histological type—8/50 predominantly comedo DCIS showed a discrepancy greater than 20 mm compared with 15/32 predominantly micropapillary/cribriform. In view of the frequently large size, adequate excision of many DCIS will require a wide excision involving up to a whole quadrant.

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CLINICAL PRACTICEExtent, distribution, and mammographic/ histological correlations of breast ductal carcinoma in situ

Abstract

Ductal carcinoma in situ (intraductal carcinoma) of the breast

N Engl J Med

Breast Cancer Detection Demonstration Project: five-year summary report

CA

Evaluation of overdiagnosis of breast cancer in screening with mammography

Int J Epidermiol

Duct carcinoma in situ: relationship of extent of noninvasive diseases to the frequency of occult invasion, multicentricity, lymph node metastases, and shortterm treatment failures

Cancer

Noninvasive breast carcinoma

Ann Surg

Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6). I. Intraductal carcinoma (DCIS)

Cancer

The presence of an extensive intraductal component (EIC) following a limited excision predicts for prominent residual disease in the remainder of the breast

J Clin Oncol

CLINICAL PRACTICE
Extent, distribution, and mammographic/ histological correlations of breast ductal carcinoma in situ