MEDICAL SCIENCEAssociation between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA
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Cited by (282)
Unraveling diverse roles of noncoding RNAs in various human papillomavirus negative cancers
2022, Pharmacology and TherapeuticsCitation Excerpt :Because of the great difference in molecular mechanisms of tumorigenesis between the two cancer types, the sensitivity to chemoradiotherapy and the survival outcomes of HPV negative cancer were distinct from HPV positive cancer clinically (Costa, Boroni, & Soares, 2018). In addition, a large number of surveys consistently showed that HPV negative tumor was more likely to relapse and distant metastasize, and thought to be connected with worse prognosis (Riou et al., 1990; Higgins et al., 1991; Rodriguez-Carunchio et al., 2015). In recent years, the regulatory functions of noncoding RNAs (ncRNAs) in various cellular processes have caused people's attention (Anastasiadou, Jacob, & Slack, 2018), and gradually been recognized as the important regulatory factors in the occurrence of various cancers (Martens-Uzunova et al., 2014; Chen, Lin, Shu, He, & Gao, 2020).
Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer
2018, Gynecologic OncologyCitation Excerpt :Furthermore, several studies have reported that HPV negativity was associated with poor prognosis [2,11-13]. It has also been suggested that HPV-negative cervical cancer may be represent a biologically distinct subset of tumors associated with poorer prognosis than HPV-positive cervical cancers [11,13]. However, these findings have not been supported by other studies [14].
Is HPV-negative cervical carcinoma a different type of cervical cancer?
2023, European Review for Medical and Pharmacological SciencesHPV-Positive and -Negative Cervical Cancers Are Immunologically Distinct
2022, Journal of Clinical Medicine