Elsevier

The Lancet

Volume 335, Issue 8699, 19 May 1990, Pages 1171-1174
The Lancet

MEDICAL SCIENCE
Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

https://doi.org/10.1016/0140-6736(90)92693-CGet rights and content

Abstract

Human papilloma virus (HPV) DNA sequences (HPV types 16,18, 33, 35 or uncharacterised) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2·6 times higher risk of overall relapse (p<0·05) and 4·5 times higher risk of distant metastases (p <0·01). The 24-month relapse-free survival rate in HPV-positive patients was significantly higher than that in HPV-negative patients (77% vs 40%), and the difference was similar (91% vs 56%) among those who were node-negative. These data indicate that HPV-negative cervical carcinomas may represent a biologically distinct subset of tumours that carry a poorer prognosis than do HPV-positive cancers.

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