Elsevier

The Lancet

Volume 340, Issue 8812, 18 July 1992, Pages 145-146
The Lancet

SHORT REPORT
Relation of neovascularisation to metastasis of non-small-cell lung cancer

https://doi.org/10.1016/0140-6736(92)93217-BGet rights and content

Abstract

The growth of a tumour beyond a certain size requires angiogenesis. We assessed whether intensity of angiogenesis correlates with metastasis of non-small-cell lung cancer by counting microvessels and grading their density within the initial carcinomas in 87 T1 NOMO patients. After radical surgery, metastases developed in 22. Both microvessel count and density grades correlated significantly with metastatic disease as well as tumour size and proliferative activity. The likelihood of metastasis increased as the vessel count increased. On multivariate analysis, the microvessel density count was the only independent predictor of metastasis.

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