Translocation involving chromosome 22 in Ewing's Sarcoma. A cytogenetic study of four fresh tumors☆
References (9)
- et al.
Recent advances in molecular pathology: A review. Some aspects of chromosome changes in Cancer
Exp Molec Pathol
(1969) - et al.
Chromosome study of Ewing's Sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12)
Cancer Genet Cytogenet
(1984) - et al.
Chromosomes and causation of human cancer and leukemia
Cancer
(1976) Chromosome analysis of malignant human effusions in vivo
Scand J Resp Dis (supp)
(1979)
Cited by (186)
Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
2023, Journal of Bone OncologyMolecular aspects of Ewing’s sarcomas
2021, Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to BedsideSoft Tissue Sarcomas and Mesenchymal Neoplasms of Uncertain Histogenesis With Characteristic Translocations
2019, Practical Soft Tissue Pathology: A Diagnostic Approach A Volume in the Pattern Recognition SeriesMolecular assessment of circulating exosomes toward liquid biopsy diagnosis of Ewing sarcoma family of tumors
2018, Translational ResearchCitation Excerpt :This recipient gene encodes for a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. In approximately 90% of these lesions, the disease-associated genomic alteration is a translocation between the long arms of chromosomes 11 and 22 (t[11;22] [q24;q12]).25-27 Upon cloning of the specific breakpoints, it was shown to involve the EWS gene (EWSR1) on chromosome 22 and the FLI1 gene on chromosome 11.
Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
2018, Annals of OncologyCitation Excerpt :Molecular biology studies have shown that almost all of these tumours share a common TET-ETS gene rearrangement involving the EWSR1 gene on chromosome 22 [61–64]. In most cases, this involves a reciprocal translocation t(11; 22)(q24; q12) [47], but t(21; 22)(q22; q12), and others may also occur [t(7; 22), t(17; 22) and t(2; 22)] [61–64]. In recent years, new small round cell sarcoma entities have been recognised, with novel translocations, among which BCL6 corepressor (BCOR)-rearranged sarcoma preferentially affects the bone.
Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application
2023, Journal of Cancer Research and Clinical Oncology
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This work was supported by grants from CNRS (ERA 47 and ER 264) and Electricité de France.