Lead articleThe application of fluorescent in situ hybridization to detect Mbcr/abl fusion in variant Ph chromosomes in CML and ALL☆
References (17)
- et al.
Long-range mapping of the Philadelphia chromosome by pulsed-field gel electrophoresis
Blood
(1988) - et al.
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
Cell
(1984) - et al.
Complex chromosomal translocations in the Philadelphia chromosome leukemias: Serial translocations or a concerted genomic rearrangement?
Cancer Genet Cytogenet
(1991) - et al.
Is the chromosomal region 9q34 always involved in variants of the Ph1 translocation?
Cancer Genet Cytogenet
(1984) - et al.
Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML
Cancer Genet Cytogenet
(1991)
Cited by (115)
Monitoring the response and course of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: Practical advice on the use and interpretation of monitoring methods
2008, BloodCitation Excerpt :Studies of the association of cytogenetic response with long-term prognosis have so far relied on classic cytogenetic analysis, not on FISH-based results. Several FISH methodologies have been developed and are reviewed elsewhere.8–14 Traditional FISH uses a 5′ BCR and a 3′ ABL fluorescent probe of different colors and has a false-positive threshold of 1% to 10%.9
Guidance for fluorescence in situ hybridization testing in hematologic disorders
2007, Journal of Molecular DiagnosticsCitation Excerpt :Studies indicate that analysis of 500 nuclei with a D-FISH on bone marrow or peripheral blood can detect less than 1% neoplastic cells.2,17 Strict scoring criteria have been developed for D-FISH to reliably classify individual cells as either normal or abnormal.2,16,17 With D-FISH, normal cells have two BCR and two ABL1 signals (Figure 1A).
Conventional cytogenetics and FISH in the detection of BCR/ABL fusion in chronic myeloid leukemia (CML)
2006, Experimental and Molecular PathologyA review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology
2022, Frontiers in ImmunologyBCR/ABL Fusion Gene by FISH Technique: What is the Appropriate Cut off for Diagnosis and Monitoring Response to Treatment?
2021, Journal of the Medical Association of Thailand
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G.W.D. and S.M.J. are supported by grants from Oncor, Inc., Gaithersburg, MD.