Rapid publicationc-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma
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Cholangiocarcinoma
2017, Zakim and Boyer's Hepatology: A Textbook of Liver DiseaseCholangiocarcinoma
2012, Zakim and Boyer's HepatologyArray comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma
2011, HPBCitation Excerpt :It also suggests that, although ErbB2 was gained at a DNA level in all cases in this study, there is a further level of control of expression at a transcriptomic or proteomic level. Our findings are supported by the widely variable data from other studies of ErbB2 in CC, in which gene amplification is reported in 2–100% of cases41–45 and protein overexpression varies from none to 80%.41–58 Other CGH studies using metaphase chromosome CGH have identified CN gain in the same region in only 0–50% of cases (Fig. 4).
Gene amplification and protein overexpression of HER-2/neu in human extrahepatic cholangiocarcinoma as detected by chromogenic in situ hybridization and immunohistochemistry: Its prognostic implication in node-positive patients
2007, Annals of OncologyCitation Excerpt :While 27%–82% of tumors were found to express HER-2/neu in CC of Thai, English, Taiwanese. American, and Japanese origin [18–22], Collier et al. [17] were unable to detect the expression of membranous HER-2/neu in 10 cases of human CCs of European Caucasian origin by immunohistochemistry. In Japanese study [22], it was indicated that positive immunohistochemical (IHC) staining of HER-2/neu in CC correlated with a shorter survival.
Biliary tract cancers: Molecular profiling as a tool for treatment decisions. A literature review
2006, Cancer Treatment ReviewsCholangiocarcinoma
2006, Zakim and Boyer's Hepatology