Plasma cortisol levels and reactivation of latent Epstein-Barr virus in response to examination stress

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Abstract

In this study, we explored the possibility that glucocorticoid hormones, known to increase under stress, might be one component of the mechanism involved in induction of latent Epstein Barr virus (EBV). We obtained blood samples from 45 male medical students during examinations and approximately 3–4 weeks before the examinations (baseline) and measured antibody titers to EBV and plasma cortisol levels. We found reproducible changes in EBV, virus capsid antigen (VCA) antibody titers, with higher antibody titers observed in the examination blood samples consistent with the reactivation of latent virus. However, we found no evidence that day and night plasma cortisol values across the sampling points changed significantly from baseline to examinations. Therefore, academic stress did not elevate cortisol levels, but increases in EBV VCA antibody titers were still observed. The data suggest in these subjects that other neuropeptides or hormones were involved in the induction of latent EBV.

References (29)

  • CW Cotman et al.

    The Neuroimmune-Endocrine Connection

    (1987)
  • BA Esterling et al.

    Emotional repression, stress disclosure responses, and Epstein-Barr viral capsid antigen titers

    Psychosom Med

    (1990)
  • BA Esterling et al.

    Defensiveness, trait anxiety and Epstein-Barr viral capsid antigen titers in healthy college students

    Health Psychol

    (1993)
  • BA Esterling et al.

    Psychosocial modulation of antibody to Epstein-Barr viral capsid antigen and human herpesviruses type-6 in HIV-2-infected and at-risk gay men

    Psychosom Med

    (1992)
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