Dossier “Breast cancer”Insulin-like growth factors and breast cancer
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Cited by (90)
Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer
2017, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Moreover, its expression is required for neoplastic transformation by a number of cellular oncogenes, suggesting an obligatory role between expression of functional IGF-IR and the achievement of a transformed phenotype in a variety of tumorigenesis models [1,14–18]. Furthermore, in vitro [19–21] and animal models [22,23] have shown that inhibition of either the activation or expression of IGF-IR results in the suppression of cancer cell growth and tumor formation [1]. Another important issue is the fact that IGF-1 signaling confers resistance to many anti-neoplastic therapies, while IGF-1 deficient mice exhibit greatly reduced capacity to support cancer growth and metastasis [24–27].
Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling
2015, Chemico-Biological InteractionsCitation Excerpt :Our results indicated a crucial role of the IGF-IR in drug-sensitive and drug-resistant osteosarcoma cell lines. Activation of the IGF-IR promotes proliferation and transformation as well as cell–cell and cell-substrate interactions in cancer cells [17,18]. Conversely, the blockade of IGF signaling results in the inhibition of tumor growth [19].
IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
2017, Scientific Reports