Serial studies of the IgG subclass and functional affinity of DNA antibodies in systemic lupus erythematosus
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Cited by (36)
De-sialylated and sialylated IgG anti-dsDNA antibodies respectively worsen and mitigate experimental mouse lupus proteinuria and possible mechanisms
2022, International ImmunopharmacologyCitation Excerpt :Hence, low RAS activity associated with the three subclones of IgG anti-dsDNA antibodies induced low SIA/anti-dsDNA ratios through different gene expressions, either upregulated or downregulated. In patients with SLE, serum anti-dsDNA levels and IgG subclass anti-dsDNA antibodies have been utilized as disease activity markers and/or to reflect the severity of nephritis; however, contradictory reports, as well as clinical observations, have been documented in a significant population of patients with SLE [1,3–5]. Given the contradictory role of anti-dsDNA antibodies in the pathogenesis of lupus nephritis, our current findings further illustrated this issue.
Lupus Nephritis
2019, Chronic Renal DiseaseDNA repair and systemic lupus erythematosus
2017, DNA RepairCitation Excerpt :Interestingly, disease in SLE patients and lupus-prone mice is associated with increased isotype switching of autoreactive IgMs resulting in high titers of autoreactive IgGs and the deposition of immunocomplexes within the kidneys. Together, this leads to renal disease, which is one of the major clinical manifestations of SLE [43–47]. Class-switched antibodies to IgG confer transport into extravascular spaces, activation of the complement system, and binding to Fc receptors, providing the optimal potential for autoreactive antibodies to elicit proinflammatory and pathogenic responses [48].
Lupus Nephritis
2015, Chronic Renal DiseaseIncreased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1β
2006, Kidney InternationalCitation Excerpt :As identical concentrations of anti-DNA antibodies were used in these experiments, the data highlight the functional heterogeneity of anti-DNA antibodies at different phases of disease, and imply that anti-DNA antibodies still detectable during clinical remission might be ‘less pathogenic’. The results on IgG isotypes confirmed the predominance of IgG1 in anti-DNA antibody preparations.40, 41 Some investigators have suggested an association between IgG1 and IgG3 anti-DNA antibodies with renal disease, whereas others have observed an association between IgG2 anti-DNA antibodies and nephritic flare.40, 41