Research paperE- and P-cadherin expression in tumor tissues and soluble E-cadherin levels in sera of patients with skin cancer
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ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis
2008, Journal of Investigative DermatologyCitation Excerpt :Downregulation of E-cadherin occurs in many types of carcinoma and correlates with the transition to metastasis (Otto et al., 1993; Yonemura et al., 1995; Ryniers et al., 2002; Chen et al., 2003). Increased serum levels of soluble E-cadherin have been detected in carcinoma patients and patients with epithelial diseases, which are characterized by impaired keratinocyte adhesion such as eczematous dermatitis or psoriasis (Matsuyoshi et al., 1995; Griffiths et al., 1996; Shirahama et al., 1996; Furukawa et al., 1997; Velikova et al., 1998; Chan et al., 2003, 2005; Engelhart et al., 2005). In this paper, we demonstrate that the metalloprotease ADAM10 is critically involved in the release of E-cadherin from the surface of primary human keratinocytes.
T-cadherin negatively regulates the proliferation of cutaneous squamous carcinoma cells
2005, Journal of Investigative DermatologyCitation Excerpt :In the epidermis, E- and P-cadherin are the major components of intercellular adherence junctions (Nose and Takeichi, 1986), and are involved in morphogenesis and maintaining the structure of skin (Hirai et al, 1989). It is reported that the expressions of E- and P-cadherin are reduced in SCC, melanoma, and Paget's disease and reduction of cadherin expression is considered to be related to the detachment of carcinoma cells from the tumor mass (Shirahama et al, 1996; Furukawa, 1997). The contribution of T-cadherin to keratinocyte cell–cell adhesion, however, is not yet known.Vestal and Ranscht (1992) showed, using T-cadherin cDNA-transfected CHO cells, that T-cadherin induced calcium-dependent, homophilic adhesion, like E- or P-cadherin.
Mapping the chromosome 16 cadherin gene cluster to a minimal deleted region in ductal breast cancer
2001, Cancer Genetics and CytogeneticsImmunohistochemical detection of E-cadherin in certain types of salivary gland tumours
2006, Journal of Laryngology and OtologyNoncytotoxic Roles of Granzymes in Health and Disease
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