Interferon-γ and chronic granulomatous disease

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Abstract

The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granulomatous disease phenotype. Biochemical advances and the results of a clinical trial that established the efficacy of recombinant human interferon-γ for prophylaxis of infections in chronic granulomatous disease are the highlights of recent achievements in this area of phagocyte biology.

References (33)

  • J.T. Curnutte et al.

    Chronic Granulomatous Disease

    Adv in Hum Genet

    (1987)
  • A.W. Segal

    The Electron Transport Chain of the Microbicidal Oxidase of Phagocytic Cells and its Involvement in the Molecular Pathology of Chronic Granulomatous Disease

    J Clin Invest

    (1989)
  • S.H. Orkin

    Molecular Genetics of Chronic Granulomatous Disease

    Annu Rev Immunol

    (1989)
  • B. Royer-Pokora et al.

    Cloning the Gene for an Inherited Human Disorder — Chronic Granulomatous Disease — on the Basis of its Chromosomal Location

    Nature

    (1986)
  • M.C. Dinauer et al.

    The Glycoprotein Encoded by the X-linked Chronic Grartulomatous Disease Locus is a Component of the Neutrophil Cytochrome b Complex

    Nature

    (1987)
  • C. Teahan et al.

    The X-Linked Chronic Granulomatous Disease Gene Codes for the β-Chain of Cytochromeb-245

    Nature

    (1987)
  • M.C. Dinauer et al.

    A Missense Mutation in the Neutrophil Cytochrome b Heavy Chain in Cytochrome-Positive X-Linked Chronic Granulomatous Disease

    J Clin Invest

    (1989)
  • M.C. Dinauer et al.

    Human Neutrophil Cytochrome-b Light Chain (p22-phox): Gene Structure, Chromosomal Location, and Mutations in Cytochrome-Negative Autosomal Recessive Chronic Granulomatous Disease

    J Clin Invest

    (1990)
  • B.D. Volpp et al.

    Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

    Science

    (1988)
  • H. Nunoi et al.

    Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

    Science

    (1988)
  • J.T. Curnutte et al.

    Cytosolic Components of the Respiratory Burst Oxidase Resolution of Four Components, Two of Which are Missing in Complementing Types of Chronic Granulomatous Disease

  • B.G.J.M. Bolscher et al.

    A Phosphoprotein of M,47,000 Defective in Autosomal Chronic Granulomatous Disease, Copurifies with One of Two Soluble Components Required for NADPH:O2 Oxidoreductase Activity in Human NeutrophiLs

    J Clin Invest

    (1989)
  • R.A. Clark et al.

    Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

    N Engl J Med

    (1989)
  • B.D. Volpp et al.

    Cloning of the cDNA and Functional Expression of the 47-kilodalton Cytosolic Component of Human Neutrophil Respiratory Burst Oxidase

  • K.J. Lomax et al.

    Recombinant 47-kllodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

    Science

    (1989)
  • T.L. Leto et al.

    Cloning of a 67K Neutrophil Cytosolic Oxidase Factor and its Similarity to a Noncatalytic Region of p60c-src

    Science

    (1990)
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