Bradykinin receptors: Characterization, distribution and mechanisms of signal transduction

https://doi.org/10.1016/0955-2235(89)90013-6Get rights and content

Abstract

Bradykinin is a peptide consisting of nine amino acids. It is a member of the kinin family, a class of molecules sometimes considered to be locally acting hormones. Bradykinin acts through cell surface receptors to elicit a series of biological responses, many of which have been well characterized at the whole organ or body level. However, little is known about the bradykinin receptor itself or its mechanisms of signal transduction, its function and its tissue distribution. Increasing evidence suggests that bradykinin is a member of a group of locally produced peptides which may act in a paracrine fashion as microenvironmental modulators of cell proliferation. Evidence for this derives from studies of the interaction between bradykinin and its receptor, receptor-effector coupling systems and in vitro studies of the biological effects of bradykinin. These areas, together with questions concerning the nature and number of different types of bradykinin receptors, form the main bulk of current interest in bradykinin research and are the subject of this review. The ability of bradykinin to synergize with other growth regulating ligands will also be considered.

References (98)

  • RM Burch et al.

    Phorbol esters and diacylglycerols amplify bradykinin-stimulated prostaglandin synthesis in Swiss 3T3 fibroblasts

    J Biol Chem.

    (1988)
  • CW Tiffany et al.

    Bradykinin stimulates tumour necrosis factor and interleukin 1 release from macrophages

    FEBS Lett.

    (1989)
  • C Dettori et al.

    Regulation of glucose transport by insulin bombesin and bradykinin in Swiss 3T3 fibroblasts:involvement of protein kinase C-dependent and independent mechanisms

    Exp Cell Res.

    (1989)
  • RE Lewis et al.

    [125I]Tyr-bradykinin binding in primary rat brain cultures

    Brain Res.

    (1985)
  • R Plevin et al.

    Multiple B2 kinin receptors in mammalian tissues

    TIPS

    (1988)
  • D Demolle et al.

    Pattern of protein phosphorylation in aortic endothelial cells. Modulation by adenine nucleotides and bradykinin

    J Biol Chem.

    (1988)
  • PJ Casey et al.

    G protein involvement in receptor-effector coupling

    J Biol Chem.

    (1988)
  • BF Pobiner et al.

    Role of Ni in coupling angiotensin receptors to inhibitors of adenylate cyclase in hepatocytes

    J Biol Chem.

    (1985)
  • C Wasylyk et al.

    The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

    Cell

    (1987)
  • RJ Lefkowitz et al.

    Adrenergic receptors: Models for the study of receptors coupled to guanine nucleotide regulatory proteins

    J Biol Chem.

    (1988)
  • I Zachary et al.

    Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking

    J Biol Chem.

    (1987)
  • H Okamoto et al.

    Isolation and structure of T- kinin

    Biochem Biophys Res Commun.

    (1983)
  • T Mindroiu et al.

    A new kinin moiety in human plasma kininogens

    Biochem Biophys Res Commun.

    (1988)
  • B Bouscarel et al.

    Characterization of the angiotensin II receptor in primary cultures of rat hepatocytes

    J Biol Chem.

    (1988)
  • J Joris et al.

    Local production of immunoreactive bradykinin: two models of inflammation

    Pain

    (1987)
  • MJ Fredrick et al.

    Characterization of soluble bradykinin receptor-like binding sites

    Eur J Pharmac.

    (1987)
  • DR Lynch et al.

    Neuropeptides: Multiple molecular forms, metabolic pathways and receptors

    A Rev Biochem.

    (1986)
  • DC Perry et al.

    Identification of bradykinin receptors in mammalian brain

    J Neurochem.

    (1984)
  • Fujiwara Y, Mantione CR, Vavrek RJ, Stewart JW, Yamamura HI. Characterization of 3H-bradykinin binding sites in guinea...
  • RA Roberts et al.

    Bradykinin receptor number and sensitivity to ligand stimulation of mitogenesis is increased by expression of a mutant rat oncogene

    J Cell Sci.

    (1989)
  • D Regoli et al.

    Pharmacology of bradykinin and related kinins

    Pharmac Rev.

    (1980)
  • FJ Haddy et al.

    The effect of the kinins on the cardiovascular system

    Handbook Exp Pharmac.

    (1980)
  • AR Johnson
  • P Needleman et al.

    The mechanism and modification of bradykinin-induced coronary vasodilation

  • E Rocha et al.
  • JJ Pisano

    Chemistry and biology of the kallikrein-kinin system

  • J Margolis

    The interrelationship of coagulation of plasma and release of peptides

    Ann NY Acad Sci.

    (1963)
  • EG Erdos
  • TA Voyno-Yasenetskaya et al.

    Guanine nucleotide-dependent pertussis toxin-insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells

    FASEB

    (1988)
  • D Portilla et al.

    Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells

    J Clin Invest.

    (1988)
  • BC Tilly et al.

    Inositol phosphate metabolism in bradykinin-stimulated human A31 carcinoma cells

    Biochem J.

    (1987)
  • TR Jackson et al.

    Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line

    EMBO J.

    (1987)
  • TR Jackson et al.

    Bradykinin stimulation of inositol phosphate and calcium responses is insensitive to pertussis toxin in NG115-40IL neuronal cells

    Biochem Biophys Res Commun.

    (1988)
  • D-M Chuang et al.

    Characterization of bradykinin-induced phosphoinositide turnover in neurohybrid NCB-20 cells

    J Neurochem.

    (1988)
  • RM Snider et al.

    Bradykinin receptor-mediated cyclic GMP formation in a nerve cell population (murine neuroblastoma clone N1E-115)

    J Neurochem.

    (1984)
  • T Fu et al.

    Bradykinin-induced generation of inositol 1,4,5-trisphosphate in fibroblasts and neuroblastoma cells: effects of pertussis toxin, extracellular calcium and down-regulation of protein kinase C

    Biochem Biophys Res Commun.

    (1988)
  • RM Burch et al.

    Interleukin 1 enhances expression of the bradykinin-phospholipase A2-prostaglandin synthetase pathway and is mitogenic in Swiss 3T3 fibroblasts

    Clin Res.

    (1988)
  • M Sesishima et al.

    Effective formation of inositol 1,4,5-trisphosphate in bradykinin-stimulated fibroblasts from progressive systemic sclerotic patients

    Biochem Biophys Res Commun.

    (1988)
  • Cited by (0)

    View full text