Biochemical and Biophysical Research Communications
Atrial natriuretic peptide deposited as atrial amyloid fibrils
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Amyloidosis and Other Protein Deposition Diseases
2022, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Hematologic, Renal, and Immunologic DisordersHighly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension
2020, JACC: Basic to Translational ScienceCardiac telocytes. From basic science to cardiac diseases. I. Atrial fibrillation
2018, Annals of AnatomyCitation Excerpt :IAA is generated by the local, atrial, deposition of atrial natriuretic peptide (ANP), a substance synthesized by atrial myocytes (Kaye et al., 1986). Johansson et al. (1987) showed that amyloid atrial fibrils contain the same N-terminal amino acid sequence of the ANP, and that antisera to ANP and amyloid fibril protein, label atrial muscle cells and atrial amyloid in an identical fashion. Takemura showed, using immunocytochemistry at the electron microscopic level, that ANP is secreted by atrial myocytes, and confirmed the results using in-situ hybridization for ANP mRNA (Takemura et al., 1998).
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication
2017, Heart RhythmCitation Excerpt :Histologically, IAA is classified as EHRAS IVa (Figure 3; Table 2). Atrial natriuretic peptide is a fibrillogenic protein that forms IAA.81 Amyloid deposits are immunoreactive for ANP in most patients,17 while transthyretin, a transport protein implicated in systemic senile amyloidosis, was also identified in 10%4 (NT-pro-ANP has been identified in other studies82).
High recurrence of atrial fibrillation in patients with high tissue atrial natriuretic peptide and amyloid levels after concomitant maze and mitral valve surgery
2017, Journal of CardiologyCitation Excerpt :Atrial amyloid deposits affect the atrial conduction and increase the risk of AF, and are associated with an increased synthesis and secretion of the atrial natriuretic peptide (ANP) [12]. ANP is a peptide hormone synthesized and secreted predominantly by atrial cardiomyocytes [13,14]. Although atrial amyloid deposits and ANP expression play important roles in the pathophysiology of AF, their clinical applications are limited because of the difficulty with their quantification.
EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication
2016, Journal of ArrhythmiaCitation Excerpt :The PV atrial reversal velocity has also been used as a measurement of LA function [317,377,379–382]. In the presence of reduced LV compliance and elevated filling pressures, atrial contraction results in significant flow reversal into the PVs [80,81]. Studies have also demonstrated that Doppler tissue imaging can be used as an accurate marker of atrial function [383,384].