Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma
References (0)
Cited by (115)
Roles of matrix metalloproteinase-7 (MMP-7) in cancer
2021, Clinical BiochemistryCancer associated fibroblast: Mediators of tumorigenesis
2020, Matrix BiologyCitation Excerpt :Uncontrolled cell proliferation is often accompanied by a loss of normal tissue architecture [68, 69]. In fact, both cancer cells and stroma cells secrete matrix modulating proteins, such as matrix metalloproteinases (MMPs) and tissue serine proteases, which are known to degrade the basement membrane and remodel the interstitial (i.e., fibroblastic) ECM, thereby altering ECM topography [70,71]. Dysregulation of ECM turnover is believed to actively promote cancer onset, which can both stimulate mutagenesis (evidence for SMT) and/or provide growth advantage to cells with mutations (in support of TOFT).
Laminin 332 in cancer: When the extracellular matrix turns signals from cell anchorage to cell movement
2020, Seminars in Cancer BiologyImmunohistochemical evidence for myofibroblast-like cells associated with liver injury induced by aflatoxin b1 in rainbow trout (Oncorhynchus mykiss)
2014, Journal of Comparative Pathology
Copyright © 1997 American Gastroenterological Association. Published by Elsevier Inc. All rights reserved.