Streptococcus pneumoniae colonization in the young child: Association with otitis media and resistance to penicillin☆,☆☆,★
Section snippets
Population
Two hundred fifteen healthy infants and children younger than 6 years of age and receiving comprehensive care in the National Institutes of Health-funded Vaccine Clinic at Vanderbilt Medical Center were enrolled in the study. The children were recruited into the clinic at birth from the normal newborn nursery of Vanderbilt University Hospital. Informed consent for participation in vaccine trials and epidemiologic studies of infectious diseases was obtained from the parents at the time of
Colonization rates with S. pneumoniae.
From September 1, 1992, to August 31, 1993, 842 nasopharyngeal cultures were obtained from the 215 children in our Vaccine Clinic. At the end of the study, the population group consisted of 25% younger than 1 year of age, 29% ages 1 to 2 years, 23% ages 2 to 3 years, 14% ages 3 to 4 years, and 9% ages 4 to 6 years. Eighty-six percent of the children lived in homes with one or two children; 4% lived in homes with four or more children. Data on day care attendance were not assessed. The
DISCUSSION
Although AOM and nasopharyngeal colonization with S. pneumoniae are both common in young children, the relationship between the two events remains controversial. In some studies of simultaneous nasopharyngeal and tympanocentesis cultures in children with AOM, similar organisms were isolated from the two sites.12 However, because of the high recovery rate of more than one organism from the nasopharynx, cultures from this site may not be clinically useful in predicting the exact middle ear
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From the Department of Pediatrics, Division of Infectious Diseases, and the Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
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Reprints not available from the authors.
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0022-3476/95/$5.00 + 0 9/20/66930