Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines†,††
References (25)
- et al.
Angiogenesis
J Biol Chem
(1992) - et al.
Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor)
Biochem Biophys Res Commun
(1991) - et al.
Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells
J Biol Chem
(1994) - et al.
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
J Biol Chem
(1995) - et al.
Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC—rather than PKA—activation
Biochem Biophys Res Commun
(1993) What is the evidence that tumors are angiogenesis dependent?
J Natl Cancer Inst
(1990)- et al.
Consequences of angiogenesis for tumor progression, metastasis and cancer therapy
Anticancer Drugs
(1995) - et al.
Vascular endothelial growth factor is a secreted angiogenic mitogen
Science
(1989) - et al.
Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
J Clin Invest
(1992) - et al.
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
Cancer Res
(1990)
Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells
Am J Pathol
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition
Biochem Biophys Acta
Cited by (96)
VEGFR endocytosis: Implications for angiogenesis
2023, Progress in Molecular Biology and Translational ScienceCell phone use and risk of thyroid cancer: a population-based case–control study in Connecticut
2019, Annals of EpidemiologyCitation Excerpt :Alterations in TSH levels have been linked to an increased risk of thyroid cancer although the results from epidemiologic studies have been inconsistent [37–40]. Although the mechanisms linking TSH levels to thyroid cancer have not been fully understood, higher TSH may promote cancer growth [41]. In addition, TSH can stimulate the generation of hydrogen peroxide (H2O2) in the thyroid gland [42].
Regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling
2012, Molecular and Cellular EndocrinologyCitation Excerpt :In this paper we examine the functional significance of VEGFR expression in primary cultures of normal human thyroid cells. Primary cultures of human (Sato et al., 1995; Soh et al., 1996) and rat (Sato et al., 1995; Viglietto et al., 1997) thyroid follicular cells are known to produce considerable amounts of VEGFs and placental-derived growth factor (PlGF). Addition of exogenous VEGFs to cells that are producing large amounts of VEGFs, both intracellular and secreted (Susarla et al., 2011) is unlikely to have additive effects.
Estrogen activity as a preventive and therapeutic target in thyroid cancer
2012, Biomedicine and PharmacotherapyResearch progress in changes of hormone levels of patients with differentiated thyroid carcinoma during pregnancy and their effects on occurrence and development of disease
2023, Journal of Jilin University Medicine Edition
- †
Supported in part by the Leonard Rosenman MD fund, the Edwin H. Zeller fund, Mount Zion Health Systems, and the Veterans Affairs Medical Center.
- ††
Presented at the Seventeenth Annual Meeting of the American Association of Endocrine Surgeons, Napa, Calif., April 21–23, 1996.