Original contributionAltered mucin expression is a field change that accompanies mucinous (colloid) breast carcinoma histogenesis☆
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Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiation
2015, Pathology Research and PracticeCitation Excerpt :Moreover, ER and GCDFP-15 were useful markers consistent with mammary origin expressed in most of our carcinomas with SRC differentiation. Some studies have demonstrated that mucinous carcinomas have a different secretory mucin expression profile than non-mucinous carcinomas, in particular, ductal invasive carcinomas [23,24,29–32]. The epithelial cells of mucinous carcinomas were found to strongly express MUC2 and MUC6 and sometimes MUC5AC, three of the secreted gel-forming mucins, which are infrequently expressed in invasive ductal carcinomas of no special type.
The pathology of breast cancer and the role of the histopathology laboratory
2005, Clinical OncologyCitation Excerpt :Mucin genes produce a wide range of mucins; normal breast produces mucin from the Muc1 gene, a cell-membrane-bound mucin. In mucinous carcinoma, Muc2 and Muc5 genes switch to production of mucin, which is a gel-forming mucin [15]. This observation helps to explain the morphological appearances, and could also account for the good prognosis of pure mucinous carcinomas.
Pathology of Special Forms of Breast Cancer
2005, Breast CancerPathogenesis of invasive micropapillary carcinoma: Role of MUC1 glycoprotein
2004, Modern Pathology
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Supported by USPHS grants CA71195, CA40225, and CA01351. Dr Barsky is the recipient of an NCI Research Career Development Award.