Original contributionAnalysis of chromosome 9p21 deletion and p16 gene mutation in salivary gland carcinomas☆
References (19)
- et al.
Cytogenetic findings in a new case of adenoid cystic carcinoma arising in sphenoidal sinus
Cancer Genet Cytogenet
(1994) - et al.
The role of p53 mutation and protein expression in primary and recurrent adenoid cystic carcinoma
Hum Pathol
(1996) - et al.
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands
Hum Pathol
(1996) - et al.
Observations by chromosome banding, FISH and immunohistochemistry in an adenoid cystic carcinoma with del(17)(p13) as the sole deviation
Virchows Arch
(1997) - et al.
Cytogenetic findings in seven lacrimal gland neoplasms
Cancer Genet Cytogenet
(1994) - et al.
Characteristics karyotypic features in lacrimal and salivary gland carcinomas
Br J Cancer
(1994) - et al.
Rearrangement of 9p13 as the primary chromosomal aberration in adenoid cystic carcinoma of the respiratory tract
Genes Chromosom Cancer
(1991) - et al.
Allelotype of salivary gland tumors
Cancer Res
(1996) - et al.
Genotypic alterations in benign and malignant salivary gland tumors: Histogenetic and clinical implications
Am J Surg Pathol
(1997)
Cited by (52)
P16 expression and presence of lymphoid stroma are correlated with good prognosis in mucoepidermoid carcinoma of the head and neck
2023, Pathology Research and PracticeSalivary Glands
2020, Gnepp's Diagnostic Surgical Pathology of the Head and Neck, Third EditionDetailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance
2013, American Journal of PathologyCitation Excerpt :More important, the finding of common loss at the 9p21 locus, where the CDKN2A gene resides, in all three tumor types. This finding lends further evidence for the involvement of this gene in the early evolution of salivary tumors.47 We also noted a restricted loss of the 22q11.21 locus that houses the RANBP1 gene in several MECs.
Molecular advances in salivary gland pathology and their practical application
2012, Diagnostic HistopathologyCitation Excerpt :At the molecular level, most SDCs have LOH at chromosome 9p21. This chromosomal locus contains CDKN2A tumour suppressor gene that has been implicated in development or progression of SDC.38 Mutations of TP53 gene and p53 protein overexpression as well as amplification of HER-2/neu gene and HER-2/neu overexpression are common findings in SDCs.39,40
Salivary glands
2009, Modern Surgical PathologyPreferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma
2009, Human PathologyCitation Excerpt :As the p15INK4b/p16INK4a-CDK4/6-Rb and the p14ARF-MDM2-p53 pathways are intimately linked on chromosome 9p21, it makes this locus especially interesting. Functional inactivation of candidate TSGs located on chromosomal region 9p21-pter has been studied in many cancers, including CCA [5,11-14,21-23]. However, genetic and epigenetic alterations in 9p21 have never been reported in Thai patients with CCA whose geographical location, genetics, and relationship with liver fluke make the study of such genes important for the understanding of molecular carcinogenesis of liver fluke–related CCA.
- ☆
Supported by grant number 5K08CA74431-02 to C.A.M. from the National Cancer Institute. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.