Case ReportsAssociation of Human Papillomavirus Type 11 with Carcinoma of the Penis☆
Section snippets
Case report
A 58-year-old man was referred to the dermatologic clinic of the University of Rome “La Sapienza,” Rome, Italy because of the presence of a genital neoformation. Clinical examination revealed the presence of a large, nodular, exophytic lesion measuring 3 × 5 cm in diameter and involving the entire glans and infiltrating the entire penis. The remaining clinical examination revealed no abnormalities.
The patient attributed the occurrence of the symptomatic disease to about 2 months previous to
Comment
As shown in Figure 1, the verrucous carcinoma sample exhibits the same RFLP pattern as does HPV 11. After digestion with the restriction enzyme AluI (Fig. 1A), it was possible to observe that the sample does not belong in the HPV 16, 18, 31, or 33 group, but in the HPV 6 or 11 group. A second digestion with NsiI (Fig. 1B) allowed us to establish that the verrucous carcinoma HPV corresponds to HPV 11. These results were unexpected: HPV 11 had never before been associated with such an aggressive
Acknowledgements
Acknowledgment.
To Professor R. Perez-Bercoff for critically reading this manuscript.
References (15)
- et al.
The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ verrucous and invasive carcinoma of the penis
J Urol
(1995) - et al.
Detection of human papillomavirus in squamous neoplasm of the penis
J Urol
(1992) - et al.
Typing of human papillomavirus DNAs by restriction endonuclease mapping of PCR products
J Virol Methods
(1993) - et al.
Proliferating cell nuclear antigen distribution in verrucous carcinoma of the skin
Br J Dermatol
(1995) - et al.
Penile verrucous carcinoma
Arch Dermatol
(1990) Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types
Curr Top Microbiol Immunol
(1994)- et al.
High prevalence of papillomavirus associated penile intraepithelial neoplasia in sexual partners of women with cervical intraepithelial neoplasia
N Engl J Med
(1987)
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2017, European Urology, SupplementsCitation Excerpt :HPV-related precancerous lesions are associated with persistent HPV-16 and HPV-18 infection. Giant condyloma is associated with HPV-6 and HPV-11 [80]. Studies have estimated that approximately 60–100% of in situ (penile intraepithelial neoplasia [PeIN]) lesions are positive for HPV DNA [81–85].
Penile cancer-Prevention and premalignant conditions
2010, UrologyCitation Excerpt :HPV-related precancerous lesions are often associated with persistent HPV type 16 and 18 infection. Giant condylomas are associated with HPV 6 and 11 subtypes.48 In a large multicenter study of HPV DNA prevalence in penile cancer, HPV DNA was detected in 100% of condyloma cases, 90% of dysplasia cases, and 42% of penile carcinoma cases.
Molecular and genetic pathways in penile cancer
2007, Lancet OncologyCitation Excerpt :In penile carcinoma in-situ (figure 2) early carcinogenic changes are largely unknown and P53 alterations have not been seen.4 The papillary variant of squamous-cell carcinoma (SCC; figure 3) and the verrucous variant of penile SCC (figure 4) are HPV-independent neoplasms (or have undetectable HPV)5,6 showing early TP53 mutation7,8 with rapid accumulation of mutagenic events affecting unknown genetic pathways. However, the basaloid variant (figure 5) and warty variant of SCC (figure 6) are HPV-dependent neoplasms7,8 with a strong association between type of SCC and infection with HPV 16 or 18.7
Synchronous Advanced Scrotal Verrucous Carcinoma with Peripheral T-Cell Lymphoma
2007, UrologyCitation Excerpt :Condyloma acuminatum has been reported to progress to squamous cell carcinoma, as well as to VC.6,7 Furthermore, HPV has been associated with squamous cell carcinoma arising in the urogenital organs.8–10 According to reports, E6/E7 oncoproteins or p53 tumor suppressor gene mutation plays a role in the HPV-associated transition to carcinoma.10,11
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Partially supported by grants from the Institute Pasteur/Fondazione Cenci-Bolognetti of Rome and the Italian Ministero Università Ricerca Scientifica Technologica.