Association of Human Papillomavirus Type 11 with Carcinoma of the Penis

doi:10.1016/S0090-4295(98)00105-8

Urology

Volume 51, Issue 6, June 1998, Pages 1046-1048

https://doi.org/10.1016/S0090-4295(98)00105-8 Get rights and content

Abstract

Human papillomaviruses (HPVs) are epithelium-tropic viruses associated with several cutaneous, epithelial, and mucosal lesions. The oncogenic potential varies considerably among the more than 70 different genotypes so far identified. HPV 6 and 11 are generally found in benign genital condilomata or laryngeal papillomas, but they have been sporadically associated with genital malignancies. Polymerase chain reaction (PCR) primed by degenerated consensus oligonucleotides (from a late region of the HPV genome) allows one to amplify a broad spectrum of HPV, whereas the amplification with specific primers is restricted to a limited number of HPVs. Therefore, the restriction fragment length polymorphism assay permits one to identify the HPV type present in the PCR product. We report a case of an invasive verrucous carcinoma of the penis associated with HPV 11, a type previously considered noncarcinogenic.

Section snippets

Case report

A 58-year-old man was referred to the dermatologic clinic of the University of Rome “La Sapienza,” Rome, Italy because of the presence of a genital neoformation. Clinical examination revealed the presence of a large, nodular, exophytic lesion measuring 3 × 5 cm in diameter and involving the entire glans and infiltrating the entire penis. The remaining clinical examination revealed no abnormalities.

The patient attributed the occurrence of the symptomatic disease to about 2 months previous to

Comment

As shown in Figure 1, the verrucous carcinoma sample exhibits the same RFLP pattern as does HPV 11. After digestion with the restriction enzyme AluI (Fig. 1A), it was possible to observe that the sample does not belong in the HPV 16, 18, 31, or 33 group, but in the HPV 6 or 11 group. A second digestion with NsiI (Fig. 1B) allowed us to establish that the verrucous carcinoma HPV corresponds to HPV 11. These results were unexpected: HPV 11 had never before been associated with such an aggressive

Acknowledgements

Acknowledgment.

To Professor R. Perez-Bercoff for critically reading this manuscript.

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HPV-related precancerous lesions are associated with persistent HPV-16 and HPV-18 infection. Giant condyloma is associated with HPV-6 and HPV-11 [80]. Studies have estimated that approximately 60–100% of in situ (penile intraepithelial neoplasia [PeIN]) lesions are positive for HPV DNA [81–85].
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^☆: Partially supported by grants from the Institute Pasteur/Fondazione Cenci-Bolognetti of Rome and the Italian Ministero Università Ricerca Scientifica Technologica.

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Case ReportsAssociation of Human Papillomavirus Type 11 with Carcinoma of the Penis☆

Abstract

Section snippets

Case report

Comment

Acknowledgements

J Urol

J Urol

J Virol Methods

Proliferating cell nuclear antigen distribution in verrucous carcinoma of the skin

Br J Dermatol

Penile verrucous carcinoma

Arch Dermatol

Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types

Curr Top Microbiol Immunol

High prevalence of papillomavirus associated penile intraepithelial neoplasia in sexual partners of women with cervical intraepithelial neoplasia

N Engl J Med

Case Reports
Association of Human Papillomavirus Type 11 with Carcinoma of the Penis☆