Research LettersUnderestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing
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Cited by (101)
Meningococcal Biofilm Formation: Let's Stick Together
2017, Trends in MicrobiologyNeisseria
2017, Infectious Diseases, 2-Volume SetTowards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview
2017, International Journal of Infectious DiseasesCitation Excerpt :All studies aimed to rely on representative population samples, and when reported, recommended nasopharyngeal swabbing via the mouth behind the uvula (with or without tonsils).53,54 An evaluation of PCR analysis of enriched swab suspension compared to usual culture analysis found low sensitivity of conventional microbiology methods for carriage studies,55 which had already been suggested in a study comparing swabbing with immunohistochemistry after tonsillectomy.56 It is therefore likely that all existing meningococcal carriage studies have underestimated true carriage prevalence.
Neisserial Molecular Adaptations to the Nasopharyngeal Niche
2015, Advances in Microbial PhysiologyCitation Excerpt :Sim and colleagues however, using an elegant polyclonal antibody approach, demonstrated that small aggregates of the meningococcus could be identified beneath the epithelium of tonsil tissue. This observation suggests that nasopharyngeal swabbing underestimates the frequency of meningococcal carriers, and implies that these sub-epithelial bacteria represent the true reservoir of meningococci in the human nasopharynx (Sim, Harrison, Moxon, & Tang, 2000). The finding also implies that the environment of the nasopharynx makes the formation of ‘classical’ biofilm structures, such as those formed by pulmonary pathogens like P. aeruginosa in the context of CF (Yoon et al., 2002), unlikely.
Compartmental models for seasonal hyperendemic bacterial meningitis in the African meningitis belt
2019, Epidemiology and Infection