Elsevier

The Lancet

Volume 358, Issue 9295, 24 November 2001, Pages 1782-1783
The Lancet

Research Letters
Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear

https://doi.org/10.1016/S0140-6736(01)06809-XGet rights and content

Summary

We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative 1-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.

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