Elsevier

The Lancet

Volume 354, Issue 9188, 23 October 1999, Pages 1442-1443
The Lancet

Research Letters
Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas

https://doi.org/10.1016/S0140-6736(99)92824-6Get rights and content

Summary

Patients with human papillomavirus (HPV)-associated anogenital cancers had a 4·3-fold increased risk of tonsillar squamous-cell carcinoma. These cancer types also have histopathological and molecular biological similarities. Thus HPV may be aetiologically important in tonsillar carcinogenesis.

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Cited by (97)

  • Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck

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    Citation Excerpt :

    Changing sexual practices play a defining role in the unfolding of the oral- and pharyngeal oncogenic HPV epidemic. Patients with HPV associated anogenital cancer, which is more common in male homosexuals, have a higher risk for HPV-associated tonsillar cancer than for non-HPV tobacco associated oral cancers [12]. It is feasible to postulate that developing countries with their burden of sexually transmitted diseases, could be on the forefront of the unfolding global epidemic of HPV associated oropharyngeal cancers.

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