Original articleAn outbreak of multi-drug-resistant tuberculosis in a London teaching hospital
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Cited by (95)
Numerical modeling of indoor environment with a ceiling fan and an upper-room ultraviolet germicidal irradiation system
2014, Building and EnvironmentCitation Excerpt :In 2011, there were estimated 8.7 million incident cases resulting in 1.0 million deaths from TB among HIV-negative people and an additional 0.43 million HIV-positive people [1]. In recent years, the prevalence of multidrug resistant (MDR) TB strains and extensively drug resistant (XDR) TB strains [2,3], has prompted a resurgence of interest in using engineering measures to control the spread of TB, which is usually transmitted from person to person via airborne particles. This interest includes the use of ultraviolet germicidal irradiation (UVGI) to inactivate the infectious particles by damaging the DNA of the microorganisms.
Nosocomial infections and infection control
2013, Medicine (United Kingdom)Citation Excerpt :Any sputum-smear-positive TB patient who is not adequately isolated may spread the organism to other patients; unrecognized multi-drug-resistant TB poses the greatest risk, because these patients are likely to remain infectious for longer. All contacts are at risk, but the greatest risk of progression to disease is in HIV-positive and other severely immunosuppressed contacts.10 Legionella infection is acquired from the environment; transmission between patients does not occur.
Previous treatment in predicting drug-resistant tuberculosis in an area bordering East London, UK
2010, International Journal of Infectious DiseasesCitation Excerpt :However, in North London, an outbreak of isoniazid-resistant TB is on-going, with male gender, white or black Caribbean ethnicity, homelessness, time in prison, and intravenous drug use being common associations.37 Nosocomially-acquired MDR TB in cohorts of HIV-infected patients4 has been documented and, more recently, a fifth of patients with MDR TB in 2004–2005 were shown to have indistinguishable strains.2 Our findings suggest that for MDR TB, compared to overall drug resistance, a past history of treatment is potentially useful when deciding which samples to send for rifampin resistance genotyping, although a larger study is required.
Nosocomial infections
2009, MedicineCitation Excerpt :Any smear-positive TB patient who is not adequately isolated may spread the organism to other patients; unrecognized multi-drug-resistant TB poses the greatest risk, because these patients are likely to remain infectious for longer. All contacts are theoretically at risk, but the greatest risk of progression to disease is in HIV-positive and other severely immunosuppressed contacts.9 Legionella infection is acquired from the environment; transmission between patients does not occur.
Hospital and community acquired infection and the built environment - design and testing of infection control rooms
2007, Journal of Hospital InfectionControl and prevention of healthcare-associated tuberculosis: the role of respiratory isolation and personal respiratory protection
2007, Journal of Hospital InfectionCitation Excerpt :This occurred especially in hospitals with low TB admission rates, where there may have been a lower awareness of the disease.3 Outbreaks of multi-drug-resistant TB have been described in Lisbon and London hospitals in recent years.4,5 The outcome for patients was poor, due to associated HIV infection.