Elsevier

Mechanisms of Development

Volume 109, Issue 2, December 2001, Pages 413-417
Mechanisms of Development

Gene expression pattern
Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis

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Abstract

The human RUNX3/AML2 gene belongs to the ‘runt domain’ family of transcription factors that act as gene expression regulators in major developmental pathways. Here, we describe the expression pattern of Runx3 during mouse embryogenesis compared to the expression pattern of Runx1. E10.5 and E14.5–E16.5 embryos were analyzed using both immunohistochemistry and β-galactosidase activity of targeted Runx3 and Runx1 loci. We found that Runx3 expression overlapped with that of Runx1 in the hematopoietic system, whereas in sensory ganglia, epidermal appendages, and developing skeletal elements, their expression was confined to different compartments. These data provide new insights into the function of Runx3 and Runx1 in organogenesis and support the possibility that cross-regulation between them plays a role in embryogenesis.

Keywords

Runt transcription factors
AML1 and AML2
Spatio-temporal expression
Mouse embryogenesis
Tissue-specific expression
Organogenesis
Epithelial–mesenchymal interactions
Dorsal root ganglia
Cartilage
Epidermal appendages

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1

These two authors contributed equally to this work.