B cell development: signal transduction by antigen receptors and their surrogates
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Cited by (160)
B cell MHC class II signaling: A story of life and death
2019, Human ImmunologyIdentification of a secondary promoter within the human B cell receptor component gene hCD79b
2013, Journal of Biological ChemistryCitation Excerpt :The activities of these two proteins are essential for the initiation of signal transduction following BCR engagement with an antigen molecule (1). The engaged BCR triggers phosphorylation of these subunits with the subsequent triggering of clonal B cell expansion and production of secreted immunoglobulin (2). The expression of the BCR is repressed during the terminal stages of B cell differentiation, and the CD79b/CD79a encoded proteins are undetectable in terminally differentiated plasma cells (3, 4).
Copyright © 1999 Published by Elsevier Ltd.