Original Scientific ArticlesPositive peritoneal cytology predicts unresectability of pancreatic adenocarcinoma☆
Section snippets
Methods
Between January 1993 and July 1996, 228 patients referred to Memorial Sloan-Kettering Cancer Center with pancreatic tumors considered potentially resectable after dynamic, contrast-enhanced CT scan underwent laparoscopic staging and had peritoneal cytology samples sent for evaluation. Only patients who had histologically confirmed pancreatic adenocarcinoma either after resection or during laparoscopic staging were included in this study.
Results
Of the 228 patients included in this study, there were 122 females and 106 males with an average age of 64.5 ± 10.5 years. Median followup time for this study was 8.8 months. Followup for survivors was 14.4 months.
Discussion
The results of this study show that PPC in patients with pancreatic adenocarcinoma is seen mainly with advanced disease and leads to a significantly lower rate of pancreatic resection when compared with NPC. If positive, peritoneal cytology is highly specific and has a high predictive value in determining resectability. On the other hand, the sensitivity of this evaluation is lacking.
Review of the published literature assessing the role of peritoneal cytology in pancreatic adenocarcinoma is
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Human Trial of a Genetically Modified Herpes Simplex Virus for Rapid Detection of Positive Peritoneal Cytology in the Staging of Pancreatic Cancer
2016, EBioMedicineCitation Excerpt :Free cancer cells in the peritoneum are thought to arise from exfoliation of malignant cells from the primary tumor and their presence is thought to lead to the peritoneum as a frequent site of recurrence (Foo et al., 1993; Gold et al., 2007). Patients with positive peritoneal cytology (PPC) as the only evidence of metastasis have the same outcome as patients with grossly visible metastases (Ferrone et al., 2006; Merchant et al., 1999). Thus, the American Joint Commission on Cancer (AJCC) staging system for pancreatic cancer includes PPC as a criterion for M1 disease.
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Supported by an educational grant from the Milton and Bernice Stern Foundation.