Stress activated cytokines and the heart

doi:10.1016/S1359-6101(96)00043-3

Cytokine & Growth Factor Reviews

Volume 7, Issue 4, December 1996, Pages 341-354

https://doi.org/10.1016/S1359-6101(96)00043-3 Get rights and content

Abstract

The ability of myocardium to successfully compensate for, and adapt to, stress ultimately determines whether the heart will decompensate and fail, or whether it will instead maintain preserved function. Despite the importance of the myocardial response to environmental stress, very little is known with respect to the biochemical mechanisms that are responsible for mediating and integrating the stress response in the heart. In the present review we will summarize recent experimental material which suggests that cytokines that are expressed within the myocardium in response to a environment injury, namely tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6), may play an important role in initiating and integrating homeostatic responses within the heart. However, these ‘stress-activated’ cytokines all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations. Accordingly, the theme that will emerge from this discussion is that the short-term expression of stress-activated cytokines within the heart may provide the heart with an adaptive response to stress, whereas long-term expression of these molecules may be frankly maladaptive by producing cardiac decompensation.

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SurveyStress activated cytokines and the heart

Abstract

J Biol Chem

Cell

J Biol Chem

Biochim Biophys Acta

Cytokine & Growth Factor Reviews

Cell

J Mol Cell Cardiol

Immunol Today

Biochem Biophys Res Commun

J Biol Chem

J Invest Dermatol

Clin Immunol Immunopathol

Cell

J Biol Chem

J Mol Cell Cardiol

Prog Lipid Res

Cell

Biochem Biophys Res Commun

J Biol Chem

J Mol Cell Cardiol

FEBS Lett

J Biol Chem

Molecular signals for initiating protein synthesis in organ hypertrophy

The molecules that initiate cardiac hypertrophy are not species specific

Science

Isolation, characterization, and localization of heparin-binding growth factors in the heart

J Clin Invest

Cellular origin and distribution of transforming growth factor-β in the normal rate myocardium

Tissue Res

Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix

A growth factor for cardiac myocytes is produced by cardiac nonmyocytes

Cell Regul

Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts

Circ Res

Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin-II-induced hypertrophy in cultured rat cardiomyocytes

J Clin Invest

Endothelin-1 induces hypertrophy with enhanced expression of muscle specific genes in cultured neonatal rat cardiomyocytes

Circ Res

Peptide growth factors can provoke “fetal” contractile protein gene expression in rat cardiac myocytes

J Clin Invest

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival

Development

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

Tumor necrosis factor gene and protein expression in adult feline myocardium after endotoxin adminstration

J Clin Invest

Hemodynamic regulation of tumor necrosis factor-α gene and protein expression in adult mammalian myocardium

Circulation

Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia

J Clin Invest

Hypoxic stress induces cardiac myocyte-derived interleukin-6

Circulation

Induction of interleukin-6 synthesis in the myocardium

Cytokines induce stress protein formation in cultured cardiac myocytes

Basic Res Cardiol

Interleukin-1β induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture

J Clin Invest

Invertebrate cytokines: tunicate cell proliferation stimulated by an interleukin 1-like molecule

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

Science

Leukaemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury

J Mol Cell Cardiol

Tumor necrosis factor-α induced expression of heat shock protein 72 in adult feline cardiac myocytes

Am J Physiol

Interleukin I pretreatment decreases ischemia /reperfusion injury

Overexpression of the rat inducible 70-kd heart stress protein in a transgenic mouse increases the resistance of the heart to ischemia injury

J Clin Invest

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery

J Clin Invest

Survey
Stress activated cytokines and the heart