Elsevier

Human Pathology

Volume 35, Issue 2, February 2004, Pages 143-146
Human Pathology

Editorial
Accuracy and precision in HER2/neu testing in breast cancer: are we there yet?

https://doi.org/10.1016/j.humpath.2004.01.002Get rights and content

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      In current practice, HER2 status is determined through immunohistochemical and/or in situ hybridization (dual color fluorescence [FISH] or dual bright-field chromogenic in situ hybridization [DISH]) assays.8 For in situ hybridization, the necessity of manual quantification of HER2 gene amplification, while reproducible, remains a time-consuming and expensive process.9 Furthermore, with pathologists facing ever-expanding work responsibilities, combined with a shrinking number of new pathologists entering the field, there is a growing unmet need for tools to assist pathologists in managing their daily work.10–12

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