International Journal of Oral and Maxillofacial Surgery
Case ReportHead and Neck OncologyLarge cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis
Section snippets
Case report
The patient was a 79-year-old Japanese man who had had liver carcinoma (well-differentiated hepatocellular carcinoma) and hypopharyngeal carcinoma, which had been completely resected about 1 year before. Partial hepatectomy was performed, followed by total pharyngo-laryngo-esophagectomy and bilateral neck dissection for hypopharyngeal cancer that was diagnosed as moderately differentiated squamous cell carcinoma (SqCC). He had been followed up, and a mass, 10 × 10 mm, had been found on the left
Discussion
LCNECs were formally diagnosed as poorly differentiated SqCC and previous reports have pointed out that LCNEC was often misdiagnosed as poorly differentiated SqCC or poorly differentiated adenocarcinoma5, 11. Basaloid carcinoma of the lung also resembles LCNEC, but basaloid carcinoma lacks neuroendocrine features and TTF-1 expression7, 8. The diagnosis of LCNEC in the present case is based on criteria established for tumors of the lung10. The criteria included large cells, with a polygonal
Conflict interest statement
We declare that we have no conflict of interest.
Acknowledgements
The authors thank the staff of the Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan (Isamu Hayashi, Kaori Nagata, Sachiko Oono, Yoichi Watanabe, Hiroshi Tashiro, Masatake Honda, Kumiko Hirobe, Masato Abe, Mihoko Shimura, Chiho Sugiyama, Takuya Kawasaki, and Koji Muramatsu) for excellent technical assistance.
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Large cell neuroendocrine carcinoma of the floor of mouth and retromolar trigone in association with basaloid squamous cell carcinoma
2022, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :There are some histopathological differences between this case of oral cavity LCNEC and the two previous descriptions in the literature (see Table 1). The case patient’s tumor originated in the FOM and RMT, similar to that described by Krishnamurthy et al.2 Esmati et al.3 reported a LCNEC originating from the oral tongue, while Kusafuka et al.1 reported an oral cavity LCNEC originating from the base of the tongue. The tongue base is an oropharyngeal subsite, meaning there have been only two true published reports of oral cavity primary LCNEC prior to the present case report.
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2014, Journal of Oral and Maxillofacial SurgeryCitation Excerpt :In the oral cavity, Merkel cells are considered the origin, because they preferentially scatter in the basal layer of the keratinized epithelium in the hard palate and gingiva.7,11 Some researchers have proposed that LCNEC of the tongue base arises from some special cells that have neuroendocrine characteristics and are located in the basal cell layer of the squamous epithelium.23 Thus, LCNEC has been suggested to originate from neuroendocrine cells.
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2012, Oral OncologyPrimary typical carcinoid tumour in the retromolar region with prominent squamous differentiation: A case report
2011, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :The Merkel cells show a preferential distribution along the basal layer of the keratinized epithelium of the hard palate and gingiva where they are present as widely scattered clear cells occurring singly or in clusters6. The presence of a novel cluster of neuroendocrine cells with a non-Merkel cell phenotype has been recently described in the squamous epithelium of the human tongue base5. These neuroendocrine cells normally found in the oral cavity are thought by some authors to be the cells of origin of neuroendocrine carcinomas3,5,6.