Original CommunicationMicroRNA expression signatures in intraductal papillary mucinous neoplasm of the pancreas
Section snippets
Tissue samples
We used a prospective database of all patients identified as having IPMN in our institution between February 2002 and 2011. All of the tissues in our study were obtained from surgical resection specimens. A pathologist experienced in pancreatic pathology (E.B.) reviewed all histologic slides. After confirmation of a diagnosis of IPMN, the specimens were entered into the study. Histologic typing of the tumors was performed according to the classification recommended in the revised 2000 World
Differential miRNAs expression in IPMN tissues of the different grades compared with normal pancreatic tissues
We compared miRNA expression in LG, MG, HG, and invasive cancer arising in IPMN with that of normal pancreatic tissue. Fourteen differentially expressed miRNAs were found with P values <.05, and fold change cutoff 2, in all IPMN tissues compared with normal pancreas (Table I). All miRNAs were upregulated in disease tissues compared with normal pancreatic tissues. For 3 of these miRNAs (hsa-miR-10a_st, hsa-miR-146a_st, and hsa-miR-155_st), the ratio of miRNA expression in disease tissue compared
Discussion
During the past decade, a dramatic increase in the number of patients diagnosed with pancreatic cysts has been observed. Some of these lesions are benign and can be followed clinically; however, lesions such as IPMN and mucinous cystic neoplasms have the potential to progress to invasive pancreatic adenocarcinoma. These lesions, owing to their macroscopic cystic nature, enable early detection with radiologic examinations, and an opportunity for pancreatic cancer prevention. However, the lack of
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Epigenetics in precision medicine of pancreatic cancer
2021, Epigenetics in Precision MedicineCyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: A critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms
2015, Journal of the American College of SurgeonsCitation Excerpt :Assessment of formalin-fixed, paraffin-embedded sections from 65 invasive IPMNs and 16 noninvasive IPMNs supported a role for these particular microRNAs with miR-21 and miR-155 significantly overexpressed in invasive IPMN compared with noninvasive IPMN, while the contrary relationship was observed for miR-101.94 Global miRNA expression analysis was examined in a study of 10 low-grade, 5 moderate-grade, 5 high-grade, and 10 invasive IPMNs.95 Hierarchical clustering revealed 15 miRNAs that were different between low- and intermediate-grade compared with high-grade and invasive IPMNs.
Pancreatic Cancer: Genetic Conditions and Epigenetic Alterations
2023, Journal of Gastrointestinal SurgeryBlood-Based Diagnosis and Risk Stratification of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN)
2023, Clinical Cancer ResearchMir-10a in pancreatic juice as a biomarker for invasive intraductal papillary mucinous neoplasm by mirna sequencing
2021, International Journal of Molecular Sciences
This work was supported by the generous donation of the Enav Family Foundation for Pancreatic Cancer Research.