Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Homology and concerted evolution at the α1 and α2 loci of human α-globin

Nature volume 290, pages 26–29 (1981)Cite this article

Abstract

The identical structure of two racially distinct α1-globin alleles and the high degree of homology between the α1- and α2-globin loci indicate that mechanisms exist for suppression of allelic polymorphisms and for exchange of genetic information within the α-globin gene complex.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Embury, S. H., Lebo, R. V., Dozy, A. M. & Kan, Y. W. J. clin. Invest. 63, 1307–1310 (1978).

    Article  Google Scholar 

  2. Orkin, S. Proc. natn. Acad. Sci. U.S.A. 75, 5950–5954 (1978).

    Article  ADS  CAS  Google Scholar 

  3. Deisseroth, A. et al. Cell 12, 205–218 (1977).

    Article  CAS  Google Scholar 

  4. Lauer, J., Shen, C.-K. J. & Maniatis, T. Cell 20, 119–130 (1980).

    Article  CAS  Google Scholar 

  5. Dayoff, M. O. Atlas of Protein Sequence and Structure Vol. 5, D56 (National Biomedical Research Foundation, Washington, DC, 1961).

    Google Scholar 

  6. Zimmer, E. A. et al. Proc. natn. Acad. U.S.A. 77, 2158–2162 (1980).

    Article  ADS  CAS  Google Scholar 

  7. Hood, L., Campbell, J. H. & Elgin, S. C. R. A. Rev. Genet. 9, 305–353 (1975).

    Article  CAS  Google Scholar 

  8. Little, P. F. R. et al. Nature 282, 316–318 (1979).

    Article  ADS  CAS  Google Scholar 

  9. Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–639 (1980).

    Article  CAS  Google Scholar 

  10. Proudfoot, N. J. & Maniatis, T. Cell 21, 537–545 (1980).

    Article  CAS  Google Scholar 

  11. Liebhaber, S. A., Goossens, M. & Kan, Y. W. Proc. natn. Acad. Sci. U.S.A. 77, 7054–7058 (1980).

    Article  ADS  CAS  Google Scholar 

  12. Jeffreys, A. J. Cell 18, 1–10 (1979).

    Article  CAS  Google Scholar 

  13. Efstratiadis, A. et al. Cell 21, 653–669 (1980).

    Article  CAS  Google Scholar 

  14. Farabaugh, P. J. & Miller, J. H. J. molec. Biol. 126, 847–863 (1978).

    Article  CAS  Google Scholar 

  15. Proudfoot, N. J., Gillam, S., Smith, M. & Longley, J. I. Cell 11, 807–818 (1977).

    Article  CAS  Google Scholar 

  16. Liebhaber, S. A. & Kan, Y. W. (submitted).

  17. Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211–214 (1976).

    Article  ADS  CAS  Google Scholar 

  18. Kronenberg, H. M., Roberts, B. E. & Efstratiadis, A. Nucleic Acids Res. 6, 153–166 (1979).

    Article  CAS  Google Scholar 

  19. Perler, F. et al. Cell 20, 555–566 (1980).

    Article  CAS  Google Scholar 

  20. Phillips, J. A. et al. Blood 54, 1439–1445 (1979).

    PubMed  Google Scholar 

  21. Embury, S. H. et al. J. clin. Invest. 66, 1319–1325 (1980).

    Article  CAS  Google Scholar 

  22. Goossens, M. et al. Proc. natn. Acad. Sci. U.S.A. 77, 518–521 (1980).

    Article  ADS  CAS  Google Scholar 

  23. Kan, Y. W. et al. Nature 255, 255–256 (1975).

    Article  ADS  CAS  Google Scholar 

  24. Martin, S. L., Zimmer, E. A., Kan, Y. W. & Wilson, A. C. Proc. natn. Acad. Sci. U.S.A. 77, 3563–3566 (1980).

    Article  ADS  CAS  Google Scholar 

  25. Radding, C. M. A. Rev. Biochem. 47, 847–881 (1978).

    Article  CAS  Google Scholar 

  26. Hurst, D. D., Fogel, S. & Mortimer, R. K. Proc. natn. Acad. Sci. U.S.A. 69, 101–105 (1972).

    Article  ADS  CAS  Google Scholar 

  27. Chunick, A. Genetics 75, 123–131 (1973).

    Google Scholar 

  28. Baralle, F. E. Cell 12, 1085–1095 (1977).

    Article  CAS  Google Scholar 

  29. Proudfoot, N. J. & Longley, J. I. Cell 9, 733–746 (1976).

    Article  CAS  Google Scholar 

  30. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

    Article  ADS  CAS  Google Scholar 

  31. Higgs, D. R. et al. Nature 284, 632–635 (1980).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratory and Department of Medicine, University of California, San Francisco, California, 94143, USA

    Stephen A. Liebhaber, Michel Goossens & Yuet Wai Kan

Authors
  1. Stephen A. Liebhaber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michel Goossens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuet Wai Kan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liebhaber, S., Goossens, M. & Kan, Y. Homology and concerted evolution at the α1 and α2 loci of human α-globin. Nature 290, 26–29 (1981). https://doi.org/10.1038/290026a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/290026a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing