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pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Nature volume 371, pages 257–261 (1994)Cite this article

Abstract

TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression through Gl is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced ∼30-fold in human keratinocytes by treatment with TGF-β, suggesting that pi5 may act as an effector of TGF-β-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).

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  1. David Beach: To whom correspondence should be addressed.

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  1. Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Gregory J. Hannon & David Beach

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  1. Gregory J. Hannon
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Hannon, G., Beach, D. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest. Nature 371, 257–261 (1994). https://doi.org/10.1038/371257a0

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