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BMP6 orchestrates iron metabolism

The small liver peptide hepcidin is a major regulator of systemic iron homeostasis in mammals, adapting iron absorption to the body's demands. Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.

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Figure 1: Control of iron homeostasis by hepcidin in mammals.

Kim Caesar

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Camaschella, C. BMP6 orchestrates iron metabolism. Nat Genet 41, 386–388 (2009). https://doi.org/10.1038/ng0409-386

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